红花黄色素注射液治疗老年糖尿病肾病合并急性心肌梗死患者的效果

Effects of Safflower yellow injection on elderly patients with diabetic nephropathy complicated with acute myocardial infarction

目的:观察红花黄色素注射液治疗老年糖尿病肾病(DN)合并急性心肌梗死(AMI)患者的效果。方法:回顾性分析2017年8月至2019年1月商丘市第一人民医院收治的123例老年DN合并AMI患者的临床资料,按照治疗方式的不同分成对照组56例,观察组67例。对照组应用常规治疗,观察组在对照组的基础上联合红花黄色素注射液治疗。比较治疗前后两组肾功能指标水平、心功能指标水平、临床效果及不良反应发生率。结果:治疗后,两组血肌酐、尿素氮水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后10 d,两组左心室射血分数均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组左室舒张末期内径水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为91.04%,高于对照组的76.79%,差异有统计学意义(P<0.05);观察组不良反应发生率为10.45%(7/67),与对照组的3.57%(2/56)比较,差异无统计学意义(P>0.05)。结论:在常规治疗基础上采用红花黄色素注射液治疗老年DN合并AMI患者可提高治疗总有效率和改善心、肾功能指标水平的效果,优于单纯常规治疗效果。

Objective: To study effects of Safflower yellow injection on elderly patients with diabetic nephropathy(DN) complicated with acute myocardial infarction(AMI). Methods: The clinical data of 123 elderly patients with DN complicated wit AMI from August 2017 to January 2019 were retrospectively analyzed, and they were divided into control group(n=56) and observation group(n=67) according to the different treatment methods. The control group was only treated with conventional treatment, while the observation group was given Safflower yellow injection on the basis of that of the control group. The levels of renal function indexes and cardiac function indexes before and after the treatment, clinical effects, and incidence of adverse reactions were compared between the two groups. Results: After the treatment, the levels of serum creatinine and urea nitrogen in the two groups were lower than those before the treatment;those of the observation group were lower than those of the control group;and the differences were statistically significant(P<0.05). After 10 d of treatment, the left ventricular ejection fractions in the two groups were higher than those before the treatment;those of the observation group were higher than those of the control group;and the differences were statistically significant(P<0.05). The left ventricular end diastolic diameters in the two groups after the treatment were lower than that those before the treatment;those of the observation group were lower than those of the control group;and the differences were statistically significant(P<0.05). The total effective rate in the observation group was 91.04%, which was higher than 76.79% in the control group, and the difference was statistically significant(P<0.05). However, there were no significant difference in the incidence of adverse reactions between the observation group(10.45%, 7/67) and the control group(3.57%, 2/56, P>0.05). Conclusions: On the basis of the conventional treatment, the use of safflower yellow injection in the treatment of the elderly patients with DN complicated with AMI can improve the total effective rate and improve the levels of cardiac and renal function indicators. Moreover, it is superior to single conventional treatment.