胃食管反流病患者呼吸锻炼效果的meta分析

Effect of Breathing Exercise on Gastroesophageal Reflux Disease:A Meta-analysis

背景:呼吸锻炼有助于改善胃食管反流病(GERD)患者的症状,但其具体疗效和作用存在争议。目的:评价呼吸锻炼对GERD患者的疗效和作用。方法:计算机检索PubMed、Embase、Cochrane Library、Central Database、Web of Science、AMED、CINAHL、中国期刊全文数据库、中国生物医学文献数据库、万方数据知识服务平台和维普资讯中文期刊服务平台数据库,纳入有关呼吸锻炼治疗GERD的随机对照试验和队列研究。按照纳入和排除标准筛选文献并评价其质量,采用RevMan 5.3软件进行meta分析。结果:共纳入7篇随机对照试验和2篇队列研究,包括396例GERD患者。Meta分析结果显示,呼吸锻炼可短期改善GERD患者症状(WMD=1.34,95%CI:0.99~1.70,P<0.01),提高生活质量(WMD=2.65,95%CI:1.96~3.33,P<0.01),降低抑郁程度(WMD=2.42,95%CI:1.41~3.42,P<0.01),减少抑酸剂长期消耗量(WMD=-34.11,95%CI:-55.75^-12.48,P<0.05),提高LES压力(WMD=1.36,95%CI:0.82~1.91,P<0.01),增强膈肌脚张力(WMD=7.13,95%CI:6.22~8.04,P<0.01)。结论:呼吸锻炼可在一定程度上改善GERD患者症状,增强药物的治疗效果。

Background:Breathing exercise can improve the symptoms of patients with gastroesophageal reflux disease(GERD),but its specific effect and function are controversial.Aims:To evaluate the effect of breathing exercise on GERD.Methods:Randomized controlled trials(RCTs)and cohort studies on breathing exercise in treatment of patients with GERD were retrieved from PubMed,Embase,Cochrane Library,Central Database,Web of Science,AMED,CINAHL,Chinese Academic Journal Full-text Database,China Biology Medicine disc,Wanfang Data Knowledge Service Platform,and Weipu Information Chinese Journal Service Platform.The literatures were screened according to the inclusion and exclusion criteria.Meta-analysis was conducted by RevMan 5.3 software.Results:A total of 7 RCTs and 2 cohort studies involving 396 patients with GERD were included.Meta-analysis results showed that breathing exercise could relieve the short-term symptoms of patients with GERD(WMD=1.34,95%CI:0.99-1.70,P<0.01),improve the quality of life(WMD=2.65,95%CI:1.96-3.33,P<0.01),decrease the degree of depression(WMD=2.42,95%CI:1.41-3.42,P<0.01),reduce the long-term consumption of antacids(WMD=-34.11,95%CI:-55.75--12.48,P<0.05),increase LES pressure(WMD=1.36,95%CI:0.82-1.91,P<0.01),increase tension of diaphragmatic crura(WMD=7.13,95%CI:6.22-8.04,P<0.01).Conclusions:Breathing exercise can relieve the symptoms of patients with GERD and enhance the effect of medical treatment to some extent.