微卫星不稳定性与结直肠癌的研究进展

Advances in Research on Correlation of Microsatellite Instability With Colorectal Cancer

结直肠癌(CRC)在全球范围内的发病率和死亡率均较高。目前研究认为CRC是一种由各种原因造成的遗传不稳定性长期积累、共同作用所致的异质性疾病,微卫星不稳定性(MSI)是其中的主要途径之一。本文就MSI与CRC的研究进展作一综述。

Colorectal cancer(CRC)has a high morbidity and mortality rate worldwide.Current studies indicate that CRC is a heterogeneous disease caused by long-term accumulation and joint action of genetic instability caused by various reasons.Microsatellite instability(MSI)is one of the main pathways.This article reviewed the advances in research on correlation of MSI with CRC.