瑞戈非尼引起可逆性后部脑病综合征1例

Regorafenib induced posterior reversible encephalopathy syndrome:a case report

目的提高临床医生对瑞戈非尼产生可逆性后部脑病综合征的认识。方法报道1例瑞戈非尼致可逆性后部脑病综合征,结合瑞戈非尼的药理作用和临床用药情况,针对该病人个体特点对病例进行分析。结果该病人为转移性结肠癌,在口服瑞戈非尼的过程中出现了可逆性后部脑病综合征,经利尿、脱水降颅压等治疗后好转。结论在应用瑞戈非尼时,作为医务人员应详细阅读药品说明书,并了解其注意事项及不良反应。

Objective To improve clinicians’understanding of the posterior reversible encephalopathy syndrome induced by rego rafenib.Methods One case of reversible posterior encephalopathy syndrome caused by regofinil was reported.The individual char acteristics of the case was analyzed based on the pharmacological action and clinical medication of regorafenib.Results A patient with metastatic colon cancer received oral regorafenib for treatment.During the process,the patient had reversible posterior encepha lopathy syndrome.After the treatment of dehydration,decreasing intracraninal pressure,diuretic,the patient’s signs gradually stabi lized.Conclusion In the application of regofinil,medical stuff read the instructions carefully to know about the precautions and ad verse events of the drug.