阻塞性睡眠呼吸暂停低通气综合征合并高血压患者的夜间睡眠图结构特征

Association between sleep structure and hypertension in Patients with obstructive sleep apnea hypopnea syndrome

目的分析阻塞性睡眠呼吸暂停低通气综合征(Obstructive Sleep Apnea Hypopnea Syndrome,OSAHS)患者中高血压组与非高血压组的多导睡眠图指标差异。方法选取213例OSAHS患者,并根据年龄、性别、职业和婚姻状况进行匹配,最终得到样本量均为48例的高血压组和非高血压组,比较两组患者在总睡眠时长(Total Sleep Time,TST)、睡眠效率(Sleep Efficiency,SE)、睡眠片段化等相关睡眠指标上的差异。结果在OSAHS患者中,合并高血压组的TST、SE和非快速眼动睡眠期第三阶段时长方面指标低于正常血压组,睡眠后觉醒时长(Wake After Sleep Onset,WASO)和非快速眼动睡眠期第二阶段高于正常血压组,差异均具有统计学意义(P<0.05)。结论在OSAHS患者中,合并高血压患者与正常血压组患者相比,在睡眠结构(非快速眼动睡眠期各期时长和比例)、睡眠效率和睡眠连续性存在显著差异,在未来的研究中,前瞻性的研究将对这些联系进行因果关系的论证。

Objective To comparative analyze the polysomnography sleep indexes of patients with hypertension and normal blood pressure in obstructive sleep apnea hypopnea syndrome(OSAHS).Methods 151 patients with OSAHS were selected and propensity score matching was performed according to their age,gender,occupation and marital status.Finally,hypertension group and non-hypertension group both had 48 cases.The differences in sleep duration,sleep efficiency,sleep fragmentation and other related sleep indexes between the two groups were compared.Results The total sleep time(TST),sleep efficiency(SE)and the stage 3 of non-REM sleep(N3)of hypertension group were lower than those in the non-hypertension group,while wake after sleep onset(WASO)and the stage 2 of non-REM sleep(N2)were higher than those in the non-hypertension group,of which the differences were statistically significant(P<0.05);Conclusion In patients with OSAHS,the sleep architecture(non-REM sleep time and proportion),sleep efficiency and sleep continuity of patients with hypertension were different from the normal group.In future studies,prospective studies will be needed on the analysis of the causal relationship to provide more idea of treatment for OSAHS combined with hypertension patients.