后循环脑梗死患者血清HbA 1c水平与血管病变及预后的相关性

Correlation between serum HbA 1c level and vascular lesion and prognosis in patients with posterior circulation cerebral infarction

目的分析后循环脑梗死患者血清糖化血红蛋白(HbA 1c)水平与血管病变及预后的相关性。方法选取我院2016年1月至2017年12月间收治的60例后循环脑梗死患者作为研究对象,对其一般资料进行回顾性分析。根据血清HbA 1c水平的情况,分为正常组21例(<6.5%)、轻度升高组19例(6.5%~8.5%)和升高组20例(>8.5%)。比较3组的血管狭窄程度和预后情况,采用Pearson法分析血清HbA 1c水平与血管狭窄程度及预后的相关性。结果正常组血管轻度狭窄占比71.43%,中度狭窄占比28.57%,重度狭窄占比0.00%;轻度升高组血管轻度狭窄占比36.84%,中度狭窄占比52.63%,重度狭窄占比10.53%;升高组血管轻度狭窄占比25.00%,中度狭窄占比35.00%,重度狭窄占比40.00%。正常组轻度狭窄占比高于轻度升高组和升高组,升高组重度狭窄占比高于正常组和轻度升高组,差异有统计学意义(P<0.05)。正常组mRS评分为(1.10±0.24)分,轻度升高组mRS评分为(2.17±0.30)分,升高组mRS评分为(3.21±0.38)分,正常组mRS评分低于轻度升高组和升高组,升高组mRS评分为高于正常组和轻度升高组,差异有统计学意义(P<0.05)。行Pearson相关性分析发现,血清HbA 1c水平与血管病变及预后呈正相关(r分别为0.516,0.702,P<0.05)。结论后循环脑梗死患者,血清HbA 1c水平越高,血管狭窄程度越严重,mRS评分越高,预后越差。

Objective to analyze the correlation between serum glycosylated hemoglobin(HbA 1c)level and vascular lesion and prognosis in patients with posterior circulation cerebral infarction.Methods 60 patients with posterior circulation cerebral infarction admitted to our hospital from January 2016 to December 2017 were selected as the research objects and their general data were retrospectively analyzed.According to the serum HbA 1c level,there were 21 cases in the normal group(<6.5%),19 cases in the mildly elevated group(6.5~8.5%)and 20 cases in the elevated group(>8.5%).The severity and prognosis of vascular stenosis in the three groups were compared.Pearson method was used to analyze the correlation between serum HbA 1c level and the severity and prognosis of vascular stenosis.Results mild stenosis accounted for 71.43%,moderate stenosis accounted for 28.57%,and severe stenosis accounted for 0.00%in the normal group.In the mildly elevated group,mild stenosis accounted for 36.84%,moderate stenosis for 52.63%,and severe stenosis for 10.53%.In the elevated group,25.00% of the patients had mild stenosis,35.00%had moderate stenosis,and 40.00% had severe stenosis.The proportion of mild stenosis in the normal group was higher than that in the mildly elevated group and the elevated group,and the proportion of severe stenosis in the elevated group was higher than that in the normal group and the mildly elevated group,with statistically significant difference(P<0.05).The mRS score in the normal group was(1.10±0.24)points,the mRS score in the mildly elevated group was(2.17±0.30)points,and the mRS score in the elevated group was(3.21±0.38)points.The mRS score in the normal group was lower than that in the mildly elevated group and the elevated group,while the mRS score in the elevated group was higher than that in the normal group and the mildly elevated group,with statistically significant differences(P<0.05).Pearson correlation analysis showed that serum HbA 1c level was positively correlated with vascular lesions and prognosis(r=0.516,0.702,P<0.05).Conclusion in patients with posterior circulation cerebral infarction,the higher the serum HbA 1c level,the more severe the degree of vascular stenosis,the higher the mRS score,the worse the prognosis.