银屑病性关节炎患者动脉粥样硬化的机制和危险因素

Mechanism and risk factors of atherosclerosis in patients with psoriatic arthritis

流行病学研究显示,银屑病以及银屑病关节炎(PsA)患者动脉粥样硬化(AS)的危险因素(如肥胖、糖尿病、高脂血症)增加,并且主要心血管不良事件(MACE)的发病率升高。PsA与心血管疾病、代谢综合征等疾病存在着一些共同的涉及慢性炎症的通路以及细胞因子,可能是此类患者合并心血管疾病、代谢综合征的基础。本文综述了PsA患者合并AS的危险因素,为PsA患者罹患AS的监测及预防提供指导。

Epidemiological research indicated that there were rise in risk factors(such as obesity,diabetes mellitus and hyperlipidemia)of atherosclerosis(AS)and morbidity of major adverse cardiovascular events(MACE)in patients with psoriasis and psoriatic arthritis(PsA).PsA shares some common pathways involved with chronic inflammation and cytokines with cardiovascular diseases and metabolic syndrome etc.,which may be the basis of complicated cardiovascular diseases and metabolic syndrome in these patients.The present article makes a review on risk factors of PsA patients with AS,and provide guidance for monitor and prevention of AS in PsA patients.