急诊经皮冠状动脉介入联合替格瑞洛对急性心肌梗死患者LVEF水平的影响

Effect of emergency percutaneous coronary intervention combined with ticagrelor on LVEF level in patients with acute myocardial infarction

目的:探究急诊经皮冠状动脉介入(PCI)联合替格瑞洛在急性心肌梗死患者中的应用效果。方法:回顾性分析2017年4月至2018年8月于本院行急诊PCI的72例急性心肌梗死患者的临床资料,根据药物治疗方式不同分为对照组(36例,氯吡格雷治疗)和观察组(36例,替格瑞洛治疗),比较两组治疗效果、左心射血分数(LVEF)、左室舒张末径(LVEDD)及不良事件发生情况。结果:观察组治疗优良率高于对照组(97.22%比77.78%);观察组术后LVEF值高于对照组,LVEDD值低于对照组;观察组不良事件发生率(5.56%)低于对照组(22.22%),差异均有统计学意义(均 P<0.05)。 结论:急诊PCI联合替格瑞洛可有效提升急性心肌梗死患者LVEF水平,降低LVEDD水平,改善心肌灌注情况,控制不良事件发生。

Objective To investigate the effect of emergency percutaneous coronary intervention(PCI)combined with ticagrelor in patients with acute myocardial infarction(AMI).Methods The clinical data of 72 patients with acute myocardial infarction who underwent emergency PCI from April 2017 to August 2018 were analyzed retrospectively.According to the different drug treatment methods,they were divided into control group(36 cases,clopidogrel treatment)and observation group(36 cases,ticagrelor treatment).The therapeutic effects,left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),and adverse events were compared between the two groups.Results The excellent and good rate of treatment in the observation group was higher than that in the control group(97.22%vs.77.78%);after operation,the LVEF value in the observation group was higher than that in the control group,the LVEDD value was lower than that in the control group;the incidence of adverse events(5.56%)was lower than that in the control group(22.22%),with statistically significant differences(all P<0.05).Conclusion Emergency PCI combined with ticagrelor can effectively increase the level of LVEF in patients with acute myocardial infarction,decrease the level of LVEDD,improve myocardial perfusion,and control the occurrence of adverse events.