脂溶性维生素对支原体肺炎患儿促炎/抗炎平衡及Treg/Th17细胞平衡的影响

Effect of fat-soluble vitamin on balances between proinflammatory and anti-inflammatory and between Treg and Th17 cells in children with mycoplasma pneumonia

目的探讨脂溶性维生素对支原体肺炎(MPP)患儿促炎/抗炎平衡及调节性T细胞/辅助性T细胞(Treg/Th17)平衡的影响。方法选择2016年5月至2019年6月本院收治的126例支原体肺炎患儿作为研究对象,随机分为两组,各63例。对照组采用对症治疗,基于此,观察组加用脂溶性维生素治疗,比较两组促炎/抗炎平衡及Treg/Th17细胞平衡。结果治疗后,两组IFN G-γ、IL-1β水平均降低,且观察组低于对照组,两组IL-10、TGF-β、Treg/Th17水平水平均升高,且观察组高于对照组,差异均有统计学意义(均P<0.05)。结论支原体肺炎患儿采用脂溶性维生素治疗,可有效调控患儿促炎/抗炎平衡及Treg/Th17细胞平衡,利于患儿转归。

Objective To investigate the effect of fat-soluble vitamin on balances between proinflammatory and anti-inflammatory and between regulatory T cells(Treg)and helper T cells(Th17)in children with mycoplasma pneumonia.Methods 126 children with MPP who admitted into our hospital from May,2016 to June,2019 were randomly divided into a control group and an observation group,with 63 cases in each group.The control group was given symptomatic treatment,and the observation group was treated with fat-soluble vitamin based on the control group.The proinflammatory/anti-inflammatory and Treg/Th17 balances were compared between the two groups.Results After the treatment,the levels of IFNG-γand IL-1βdecreased in both groups,and were lower in the observation group than in the control group;the levels of IL-10,TGF-β,and Treg/Th17 increased in both groups,and were higher in the observation group than in the control group;and the differences were statistically significant(all P<0.05).Conclusion Fat-soluble vitamin in treatment of children with MPP can regulate proinflammatory/anti-inflammatory and Treg/Th17 balances,and promote the children’s outcomes.