肿瘤出芽与乳腺癌临床病理特征、肿瘤浸润淋巴细胞及患者预后的相关性探讨

Correlation between tumor budding and clinicopathological features of breast cancer,tumor infiltrating lymphocytes and patient prognosis

目的探讨肿瘤出芽与乳腺癌临床病理特征、肿瘤浸润淋巴细胞及患者预后的相关性。方法选取2015年1月~2017年1月我院收治的89例乳腺癌患者肿瘤组织切片和资料,在显微镜下对乳腺癌临床病理特征观察,同时分析肿瘤浸润淋巴细胞与患者预后相关性。结果乳腺癌临床病理特征与人类表皮生长因子受体2、年龄、Ki67和肿瘤大小没有相关性,脉管癌栓侵袭、淋巴结阳性、组织学分级高与乳腺癌临床病理特征存在相关性;乳腺癌肿瘤浸润淋巴细胞水平与出芽状况呈反比关系,肿瘤出芽数量越多,乳腺癌肿瘤浸润淋巴细胞水平越低,肿瘤出芽数量越少,乳腺癌肿瘤浸润淋巴细胞水平越高;经随访,高肿瘤出芽组无病生存率为90%,低肿瘤出芽组无病生存率为98%,两组生存率存在明显差异,患者预后与乳腺癌肿瘤出芽水平存在相关性。结论乳腺癌肿瘤浸润淋巴细胞水平与出芽状况呈负相关,乳腺癌肿瘤恶性程度与出芽水平存在相关性,与恶性程度高的临床病理指标密切相关,可对患者预后产生影响。对肿瘤出芽与乳腺癌临床病理特征、肿瘤浸润淋巴细胞及患者预后的相关性探讨,可为患者临床治疗提供更有效理论依据和重要基础。

Objective To explore the correlation between tumor budding and the clinicopathological features of breast cancer,tumor infiltrating lymphocytes and patient prognosis.Methods The tumor tissue sections and data of 89 breast cancer patients treated in our hospital from January 2015 to January 2017 were selected,and the clinical and pathological characteristics of breast cancer were observed under a microscope.The correlation between tumor infiltrating lymphocytes and patient prognosis was also analyzed.Results The clinical characteristics of breast cancer were not related to human epidermal growth factor receptor 2(HER-2),age,Ki67 and tumor size.There was a correlation between vascular tumor thrombus invasion,lymph node position,tissue high grades and clinical characteristics of breast cancer.The level of breast cancer tumor infiltrating lymphocytes had an inverse relationship with the budding status.The more tumor buds,the lower the level of breast cancer tumor infiltrating lymphocytes.The lower the number of tumor buds,and the higher the level of cancer infiltrating lymphocytes.After follow-up,the disease-free survival rate of the high tumor budding group was 90%,and the disease-free survival rate of the low tumor budding group was 98%.There was a significant difference in survival rates between the two groups.There was a correlation between patient prognosis and breast cancer tumor budding level.Conclusion The level of infiltrating lymphocytes of breast cancer is inversely related to the budding status.There is a correlation between the malignant degree of breast cancer tumors and the budding level,and it is closely related to the clinicopathological indicators of high malignancy,which can affect the prognosis of patients.The study of the correlation between tumor budding and the clinicopathological characteristics of breast cancer,tumor infiltrating lymphocytes and patient prognosis can provide more effective theoretical basis and important foundation for clinical treatment of patients.