肠道病毒溶瘤机制的研究进展

Progress on oncolytic mechanism of enteroviruses

肠道病毒是引起人类无症状或轻微病变的病毒,以此为基础的溶瘤病毒已受到广泛关注。大量实验结果显示,利用肠道病毒靶向杀伤肿瘤(溶瘤)具有较好的安全性和有效性,但不同肠道病毒作为溶瘤病毒的作用机制尚不完全清楚。本文就溶瘤性肠道病毒的分子机制、肠道病毒的改造与临床试验等方面的研究进展进行综述。

As infection by enteroviruses being asymptomatic or causing mild lesions in human beings,enterovirus-based oncolytic viruses have received extensive attentions.A large number of experimental results demonstrated that it is safe and effective way to use enterovirus to treat tumor.The oncolytic mechanism of different enterovirus remains open.In this paper,the molecular mechanism of oncolytic enterovirus,modification of enterovirus and clinical trials are reviewed.