极速脉搏波技术评价慢性肾功能衰竭血液透析继发甲状旁腺功能亢进患者颈动脉僵硬度的研究

Study of ultrafast pulse wave velocity technique evaluating the stiffness of carotid wall in renal failure patients with secondary hyperparathyroidism after maintenance hemodialysis

目的探讨超声极速脉搏波技术定量评价慢性肾功能衰竭维持性血液透析(MHD)继发甲状旁腺功能亢进(SHPT)患者颈动脉血管壁僵硬度情况。方法选取慢性肾功能衰竭MHD继发SHPT的30例患者(MHD组)和34例健康志愿者(对照组),采用极速脉搏波技术测量两组颈动脉收缩起始时脉搏波速度(PWV-BS)和收缩结束时脉搏波速度(PWV-ES),结果进行对比分析。结果与对照组比较,MHD组PWV-BS和PWV-ES均明显升高[(5.96±1.11)m/s vs.(5.34±1.22)m/s,(8.03±0.33)m/s vs.(6.24±0.25)m/s],差异均有统计学意义(均P<0.05),且PWV-ES较PWV-BS升高更明显。结论极速脉搏波技术可定量评价慢性肾功能衰竭MHD继发SHPT患者的颈动脉僵硬度改变,为其相关心血管事件的预防及早期干预提供参考依据。

Objective To investigate ultrafast pulse wave velocity(ufPWV) technique evaluating the stiffness of carotid wall in renal failure patients with secondary hyperparathyroidism after undergoing maintenance hemodialysis(MHD).Methods A total of 30 patients with secondary hyperparathyroidism in chronic renal failure after receiving MHD(MHD group)were enrolled.34 age and sex matched healthy volunteers were selected as control group.ufPWV was used to measure and compare the pulse wave velocity of the beginning-systole(PWV-BS) and the pulse wave velocity of the end-systole(PWV-ES).Results Compared with the control group,PWV-BS and PWV-ES of MHD group were increased significantly [(5.96±1.11)m/s vs.(5.34±1.22) m/s,(8.03±0.33) m/s vs.(6.24±0.2.5) m/s],and the differences were statistically significant(both P<0.05).The increasing of PWV-ES was significantly higher than that of PWV-BS.Conclusion ufPWV technique can be used to quantitatively evaluate the stiffness of carotid wall in renal failure patients with secondary hyperparathyroidism after receiving MHD,which provides the prevention of cardiovascular events and references for early intervention.