泼尼松联合环磷酰胺治疗肾病综合征并肾功能不全临床疗效分析

Clinical Efficacy of Prednisone Combined with Cyclophosphamide in the Treatment of Nephrotic Syndrome with Renal Insufficiency

目的探究肾病综合征并肾功能不全患者联合采用泼尼松及环磷酰胺治疗的临床疗效。方法方便选取该院2016年3月-2019年3月接收的30例肾病综合征伴肾功能不全患者作为研究样本,按照随机化原则分为参照组和干预组,参照组(n=15)采用泼尼松治疗,干预组(n=15)联合采用泼尼松和环磷酰胺治疗。比较两组治疗效果、临床指标和不良反应发生率。结果治疗后,干预组总疗效86.67%高于参照组的53.33%,差异有统计学意义(χ^2=3.968,P=0.046);临床指标优于参照组,不良反应发生率60.00%高于参照组的20.00%,差异有统计学意义(χ^2=5.000,P=0.025)。结论泼尼松、环磷酰胺联用于肾病综合征并肾功能不全患者中疗效显著,但不良反应较多,建议临床使用时加强观察。

Objective To investigate the clinical efficacy of prednisone and cyclophosphamide in patients with nephrotic syndrome and renal insufficiency.Methods Thirty patients convenient selection with nephrotic syndrome with renal insufficiency received from March 2016 to March 2019 were enrolled in the study.They were divided into reference group and intervention group according to the randomization principle.The reference group(n=15)was adopted prednisone treatment,intervention group(n=15)combined with prednisone and cyclophosphamide.The treatment effects,clinical indicators and incidence of adverse reactions were compared between the two groups.Results After treatment,the total efficacy of the intervention group was 86.67%higher than that of the reference group 53.33%and the difference was statistically significant(χ^2=3.968,P=0.046).The clinical index was superior to the reference group.The incidence of adverse reactions was 60.00%higher than that of the reference group 20.00%,and the difference was statistically significant(χ^2=5.000,P=0.025).Conclusion Prednisone and cyclophosphamide are effective in patients with nephrotic syndrome and renal insufficiency,but there are many adverse reactions.It is recommended to strengthen observation during clinical use.