血液透析联合血液灌流在维持性血液透析患者钙磷代谢紊乱治疗中的应用研究

Application of Hemodialysis Combined with Hemoperfusion in the Treatment of Calcium and Phosphorus Metabolism Disorders in Maintenance Hemodialysis Patients

目的探讨在维持性血液透析患者钙磷代谢紊乱的治疗中,采用血液透析联合血液灌流的临床应用和效果。方法方便选取2018年1—12月来该院治疗的尿毒症患者160例,患者均采用维持性血液透析治疗,将患者随机平均分为观察组和对照组,两组患者采用不同治疗方法,对照组采用血液透析治疗,观察组患者采用血液灌流联合血液透析治疗,将两组治疗前后的临床指标,以及两组间的临床效果进行对比。结果观察组患者钙磷代谢指标改善显著,经治疗后,观察组患者各项指标改善状况为血磷(0.73±0.51)mmol/L,相较于对照组的血磷(1.21±1.92)mmol/L,观察组治疗效果具有明显优势,差异有统计学意义(t=2.413,P<0.05);治疗后两组患者血尿素氮(BUN)、肌酐(Scr)、血清β2微球蛋白(β2-MG)均有所下降,且观察组治疗效果明显优于对照组,差异有统计学意义(P<0.05);治疗6个月后,两组患者血清骨代谢标记物(P1NP、β-CTX)、骨生长蛋白(BGP)指标改善明显,且改善程度明显优于对照组,差异有统计学意义(P<0.05)。结论在血液维持性透析患者的治疗中,采用血液透析联合血液灌流治疗显著,患者各项指标均得到明显改善,钙磷代谢紊乱得到有效纠正。

Objective To investigate the clinical application and effect of hemodialysis combined with hemorrhage in the treatment of calcium and phosphorus metabolism disorders in maintenance hemodialysis patients.Methods convenient selected total of 160 patients with uremia who were treated in the hospital from randomly January to December 2018 were enrolled.The patients were treated with maintenance hemodialysis.The patients were divided into observation group and control group.The two groups used different treatment methods.The control group was treated with hemodialysis.The patients in the observation group were treated with hemoperfusion combined with hemodialysis.The clinical indexes before and after treatment and the clinical effects between the two groups were compared.Results The calcium and phosphorus metabolism index of the observation group improved significantly.After treatment,the improvement of various indicators in the observation group was blood phosphorus(0.73±0.51)mmol/L,compared with the blood phosphorus of the control group(1.21±1.92)mmol/L.There was a significant advantage,the difference was statistically significant(t=2.413,P<0.05);after treatment,blood urea nitrogen(BUN),creatinine(Scr),serum β2 microglobulin(β2-MG)decreased in both groups.The treatment effect of the observation group was significantly better than that of the control group.The difference was statistically significant(P<0.05).After 6 months of treatment,serum bone metabolism markers(P1NP,β-CTX)and bone growth protein(BGP)were used in the two groups.The improvement of the index was obvious,and the improvement degree was significantly better than that of the control group,the difference was statistically significant(P<0.05).Conclusion In the treatment of patients with hemodialysis dialysis,hemodialysis combined with blood perfusion therapy is significant,all the indicators of patients are significantly improved,and the disorder of calcium and phosphorus metabolism is effectively corrected.