HIV/AIDS免费抗病毒治疗效果及影响因素分析

Analysis of the Effect of HIV/AIDS Free Antiviral Therapy and its Influencing Factors

目的探讨HIV/AIDS免费抗病毒治疗效果及影响因素。方法导出2015年1月-2018年12月该院坚持接受抗病毒治疗HIV/AIDS患者资料1 200例,对资料进行回顾性分析,探讨影响抗病毒治疗效果因素,并比较治疗前、治疗6、12个月后患者体内CD4+T淋巴细胞数量。结果经分析,年龄、CD4+T淋巴细胞基线水平、漏服药物等因素为影响HIV/AIDS免费抗病毒疗效主要因素,治疗前,HIV/AIDS患者CD4+T淋巴细胞数为(243.57±131.57)个/μL,经治疗6个月为(364.59±155.18)个/μL,治疗12个月后为(378.42±176.98)个/μL,相比治疗前,患者CD4+T淋巴细胞数治疗后数值上升明显,与治疗前相比,治疗6个月、12个月后差异有统计学意义(t1=14.78、t2=9.31,P<0.05)。结论应用抗病毒治疗能够稳定HIV/AIDS者病情,其影响因素主要为接受抗病毒治疗年龄、CD4+T淋巴细胞基线水平、漏服药物等,在开展抗病毒治疗过程中,应重视上述因素,予以适当措施,以稳定患者病情。

Objective To investigate the effect and influence factors on free antiviral therapy for HIV/AIDS. Methods Data of 1200 patients who insisted on receiving antiviral therapy for HIV/AIDS in the hospital from January 2015 to December2018 were exported and retrospective analyzed. The influence factors on the effect of antiviral therapy were investigated.The counts of CD4+T cells before therapy and 6 months and 12 months after therapy were compared. Results After analysis,factors such as age, baseline levels of CD4+T lymphocytes, and missed medications were the main factors affecting the free antiviral efficacy of HIV/AIDS. Before treatment, the number of CD4+T lymphocytes in HIV/AIDS patients was(243.57±131.57)/μL,(364.59±155.18) cells/μL after 6 months of treatment, and(378.42±176.98) cells/μL after 12 months of treatment. Compared with before treatment, the number of patients with CD4 +T lymphocytes increased significantly after treatment, and Compared with before treatment, the difference was statistically significant after 6 months and 12 months of treatment(t1=14.78, t2=9.31, P<0.05). Conclusion The application of antiviral therapy can stabilize the condition of patients with HIVS/AIDS. The major influence factors are the age of receiving antiviral therapy, baseline level of CD4+T cells and missed doses. During the antiviral therapy, attention should be paid to the above factors and appropriate measures should be taken to stabilize the patient’s condition.