莫沙必利治疗功能性消化不良对近端胃舒张和胃排空功能的影响研究

A Study on the Effect of Moxipiril on Functional Dyspepsia in the Treatment of Proximal Gastric Diastolic and Gastric Emptying Functions

目的分析并探究莫沙必利治疗功能性消化不良对近端胃舒张和胃排空功能的影响。方法该次实验方便选取该院在2016年5月-2018年5月收入治疗的84例功能性消化不良患者,并将患者随机分为观察组和对照组,对照组患者使用吗丁啉多潘立酮片进行治疗,观察组患者使用莫沙必利进行治疗,在治疗结束后检测两组患者患者的近端胃舒张和胃排空功能,并将结果记录统计、对比分析。结果该次实验中对照组患者的总有效率为27例(64.29%);观察组患者的总有效率为35例(83.33%),差异有统计学意义(χ~2=3.941,P<0.05)。观察组患者在治疗后的胃底气体评分为(0.43±0.24)分,近端胃半排空时间为(75.26±17.28)%;对照组患者的胃底气体评分为(0.61±0.32)分,近端胃半排空时间为(57.12±16.42)%,观察组患者的胃底气体评分和近端胃半排空时间得分明显优于对照组,且差异有统计学意义(t=2.916、4.932,P<0.05)。两组患者在0 min的近端胃容积差异无统计学意义(P>0.05),两组患者在10 min、30min、60 min治疗前后均差异有统计学意义(P<0.05),且观察组患者相关的指标均优于对照组患者,差异有统计学意义(P<0.05)。结论使用莫沙必利对功能性消化不良患者进行治疗的治疗效果明显优于使用吗丁啉多潘立酮片进行治疗的患者,对患者的近端胃舒张和胃排空功能有显著的改善,值得在临床中大力推广使用。

Objective To analyze and explore the effect of moxapride on proximal gastric diastole and gastric emptying in patients with functional dyspepsia. Methods This experiment to convenient select the hospital in May 2016 to May 2018,included treatment of 84 patients with functional dyspepsia, and patients were randomly divided into observation group and control group, the control group of patients use ding Lin Pan Li methadone treatment, observation group of patients using moser will benefit for treatment, detection of two groups of patients after the treatment of patients with proximal stomach diastolic and function of gastric emptying, and record the result statistics, comparison and analysis. Results The total effective rate in the control group was 27 cases(64.29%). The total effective rate in the observation group was 35 cases(83.33%),and the difference was statistically significant(χ~2=3.941, P<0.05). In the observation group, the gastric fundus gas score after treatment was(0.43±0.24)points, and the proximal gastric emptying time was(75.26±17.28) %. The gastric fundus gas score of patients in the control group was(0.61±0.32)points, and the proximal gastric emptying time was(57.12±16.42) %.The gastric fundus gas score and proximal gastric emptying time score of patients in the observation group were significantly better than those in the control group, and the difference was statistically significant(t=2.916,4.932, P<0.05). There was no statistically significant difference in proximal gastric volume between the two groups at 0 min(P>0.05), and there was statistically significant difference between the two groups before and after treatment at 10 min, 30 min, and 60 min(P<0.05), and the relevant indicators in the observation group were better than those in the control group(P<0.05). Conclusion The therapeutic effect of moxapride on patients with functional dyspepsia is significantly better than that of the patients treated with moxapride doperidone tablets, which can significantly improve the function of proximal gastric diastole and gastric emptying,and is worthy of being widely used in clinical practice.