地西他滨治疗老年急性髓系白血病的临床疗效和安全性分析研究

Clinical Efficacy and Safety Analysis of Diacetabine in the Treatment of Elderly Acute Myeloid Leukemia

目的研究地西他滨治疗老年急性髓系白血病的临床疗效和安全性。方法该院在2016年4月-2019年3月收治的老年急性髓系白血病患者中方便选取43例作为研究对象,按照患者意愿分两组观察组和对照组,观察组22例,对照组21例。对照组采用常规化疗治疗,观察组在常规治疗的基础上加用地西他滨治疗。对比两组的治疗有效率、不良反应发生率、病情反复发作状况。结果观察组与对照组比较,观察组的治疗有效率为95.45%,对照组的治疗有效率为61.90%,观察组的治疗有效率高,差异有统计学意义(χ~2=7.308,P=0.007);观察组的不良反应发生率为9.09%,对照组的不良反应发生率为52.38%,观察组的不良反应发生率低,差异有统计学意义(χ~2=10.282,P=0.001);观察组的病情反复发作有1例,对照组的病情反复发作有7例,观察组的病情反复发作次数少,可以有效地促进患者的顺利康复(χ~2=5.880,P=0.015)。各项对比差异有统计学意义(P<0.05)。结论在常规化疗治疗的基础上加用地西他滨,可以明显的增加治疗有效率,降低不良反应和病情反复发作的几率,有较好治疗效果且用药安全性高,在临床的实用价值显著,应该进一步推广应用。

Objective To study the clinical efficacy and safety of diacetabine in the treatment of acute myeloid leukemia in the elderly. Methods Convenient select 43 patients with acute myeloid leukemia were selected from April 2016 to March2019 in the hospital. They were divided into two groups of observation group and control group according to the patient’s wishes. 22 cases in the observation group and 21 cases in the control group were treated with conventional chemotherapy.The observation group added sitabine to the treatment on the basis of routine treatment, and compared the treatment efficiency, adverse reaction rate, and recurrent symptoms of the two groups. Results Compared with the control group, the effective rate of treatment was 95.45% in the observation group, 61.90% in the control group, and the effective rate of treatment in the observation group was more higher,the difference was statistically significant(χ~2=7.308, P=0.007). The adverse reaction rate in the observation group was 9.09%. The incidence of adverse reactions in the control group was 52.38%, and the incidence of adverse reactions was low in the observation group,the difference was statistically significant(χ~2=10.282, P=0.001). There were 1 case recurrent episodes in the observation group, and 7 cases recurrent episodes in the control group,the observation group has a small number of recurrent episodes, which can effectively promote the patient’s smooth recovery(χ~2=5.880, P =0.015). The differences were statistically significant(P <0.05). Conclusion On the basis of conventional chemotherapy, adding sitabine can effectively increase the efficiency of treatment, reduce the chance of adverse reactions and relapse, have better treatment effect and high drug safety, and have significant practical value in clinical practice. Applications should be further promoted.