不同剂量甲泼尼龙治疗小儿重症过敏性紫癜的效果分析

The Analysis Effects of Different Doses of Methylprednisolone on Severe Allergic Purpura in Children

目的分析不同剂量甲泼尼龙治疗小儿重症过敏性紫癜的效果。方法方便选取该院2016年3月-2019年3月收治的48例小儿重症过敏性紫癜患儿,随机分为观察组和对照组,每组24例,对照组行常规甲泼尼龙治疗,观察组行甲泼尼龙递减治疗。对比两组患儿的治疗有效率、不良反应发生率、住院时间、临床症状消失时间。结果观察组患儿的治疗有效率为95.83%(23/24),对照组患儿治疗有效率为79.17%(19/24),两组对比差异有统计学意义(χ~2=10.225,P<0.05)。观察组患儿不良发应发生率为25.00%(6/24),对照组为41.67%(10/24),两组对比差异有统计学意义(χ~2=11.681,P<0.05)。观察组患儿住院时间为(9.7±1.3)d、临床症状消失时间为(8.1±1.6)d,对照组患儿住院时间为(12.2±1.5)d、临床症状消失时间为(9.2±1.9)d,两组对比差异有统计学意义(t=14.883、12.367, P<0.05)。结论不同剂量甲泼尼龙,治疗小儿重症过敏性紫癜的效果存在差异,递减给药的方式效果更理想,患儿住院时间和临床症状消失时间较短,治疗有效率高,不良反应发生率低。

Objective To analyze the effect of different doses of methylprednisolone on severe allergic purpura in children.Methods Convenient selection of 48 children with severe allergic purpura in children admitted to the hospital from March 2016 to March 2019 were randomly divided into observation group and control group, with 24 cases in each group. The control group received routine methylprednisolone treatment, and the observation group received methylprednisolone decline treatment.The effective rate of treatment, incidence of adverse reactions, length of stay and time of disappearance of clinical symptoms were compared between the two groups. Results The effective rate was 95.83%(23/24) in the observation group and 79.17%(19/24) in the control group, showing statistically significant differences between the two groups (χ~2=10.225,P<0.05).The incidence of adverse events was 25.00%(6/24) in the observation group and 41.67%(10/24) in the control group,with statistically significant differences between the two groups (χ~2=11.681,P<0.05).The length of stay in the observation group was(9.7±1.3) d and the time of disappearance of clinical symptoms was(8.1±1.6) d, while the length of stay in the control group was(12.2±1.5) d and the time of disappearance of clinical symptoms was(9.2±1.9) d. The differences between the two groups were statistically significant(t=14.883、12.367, P<0.05). Conclusion Different doses of methylprednisolone have different effects in treating severe allergic purpura in children, and the effect of decreasing administration is more ideal, the hospital stay and clinical symptom disappear time are shorter, the treatment efficiency is high, and the incidence of adverse reactions is low.