埃索美拉唑与奥美拉唑在胃溃疡治疗中的应用价值比较

Comparison of the value of esomeprazole and omeprazole in the treatment of gastric ulcer

目的研究对比埃索美拉唑与奥美拉唑在胃溃疡治疗中的应用效果及价值。方法选取2017年7月至2018年12月本院收治的84例胃溃疡患者,采用随机数字表法分为实验组与参照组,各42例。实验组予以埃索美拉唑治疗,参照组予以奥美拉唑治疗,疗程均为4周,对比两组患者治疗总有效率、炎性因子水平及不良反应发生率。结果实验组治疗总有效率为97.62%,高于参照组的83.33%,实验组患者治疗1周后IL-8、TNF-α水平均低于参照组,组间比较差异具有统计学意义(P<0.05);实验组患者不良反应发生率为9.52%,参照组为11.90%,比较差异无统计学意义。结论在胃溃疡患者的治疗中,埃索美拉唑的疗效优于奥美拉唑,前者能更好地清除幽门螺杆菌,促进机体炎性反应消退,值得推广。

Objective To study the effect and value of esomeprazole and omeprazole in the treatment of gastric ulcer.Methods 84 patients with gastric ulcer admitted to our department from July 2017 to December 2018 were divided into the experimental group and the control group by random number table,with 42 cases in each group.The experimental group was treated with esomeprazole and the control group with omeprazole for 4 weeks.The total effective rate,the level of inflammatory factors and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the experimental group(97.62%)was higher than that of the control group(83.33%).The levels of IL-8 and TNF-a in the experimental group were lower than those in the control group after one week of treatment.The incidence of adverse reactions was 9.52%in the experimental group and 11.90%in the control group,the difference was not statistically significant.Conclusion Esomeprazole is better than omeprazole in the treatment of patients with gastric ulcer.The former can remove Helicobacter pylori better,promote the regression of inflammatory reaction,and is worth promoting.