肿瘤坏死因子和血管紧张素Ⅱ与慢性肝衰竭患者并Ⅰ型HRS肝肾功能相关性分析

The correlation research on the type 1 HRS with levels of TNF-αand AngⅡin CLF patients

目的检测慢性肝衰竭(chronic liver failure,CLF)与Ⅰ型肝肾综合征(hepatorenal syndrome,HRS)患者血清肿瘤坏死因子-α(TNF-α)、血管紧张素Ⅱ(AngⅡ)水平变化,并进行TNF-α、AngⅡ与肝肾功能的相关性分析。方法选取2014年6月至2018年12月于本院住院的CLF并Ⅰ型HRS患者30例(CLF+HRS组),另选取同期住院的CLF无肾功能损害的患者30例(CLF组),检测对比两组患者肝肾功能指标、血清TNF-α、AngⅡ含量,并与肝肾功能指标水平进行相关性分析。结果CLF+HRS组TNF-α、AngⅡ、Scr水平均高于CLF组,Ccr水平低于CLF组,差异具有统计学意义(P<0.05);两组各项肝功能指标比较差异无统计学意义;两组患者血清TNF-α、AngⅡ含量与Scr、TBIL呈正相关,与Ccr、PTA呈负相关(P<0.05)。结论TNF-α、AngⅡ水平均与CLF患者Ⅰ型HRS密切相关。

Objective To detect serum tumor necrosis factor-α(TNF-α) and angiotensin Ⅱ(AngⅡ) in patients with chronic liver failure(CLF)and type I hepatorenal syndrome(HRS) level changes, and correlation analysis between TNF-α, AngⅡ and liver and kidney function. Methods 30 patients with CLF without renal impairment(CLF group) and 30 patients with CLF and type I HRS(CLF+HRS group) who were hospitalized in Ninth Hospital of Nanchang from June 2014 to December 2018 were selected. The liver and kidney function indexes, serum TNF-α and AngⅡ levels were measured and compared in the two groups, and the correlation between TNF-α and AngⅡ levels and liver and kidney function was analyzed.Results The levels of TNF-α, AngⅡ and Scr in CLF+HRS group were higher than those in CLF group, and the levels of Ccr were lower than those in CLF group, with statistical significance(P<0.05). There was no significant difference in liver function between the two groups. The serum levels of TNF-α and AngⅡ were positively correlated with Scr and TBIL, negatively correlated with CCr and PTA(P<0.05). Conclusion TNF-α and AngⅡ levels are closely related to patients with CLF combined 1 HRS.