TCT+HPVL1壳蛋白检测诊断疑似宫颈病变的应用价值

Value of TCT+HPVL1 chitin detection in diagnosis of suspected cervical lesions

目的探讨液基薄层细胞学(TCT)+人乳头瘤病毒L1(HPVL1)壳蛋白检测诊断宫颈病变的应用价值。方法选取2018年2月至2019年2月本院收治的疑似宫颈病变患者268例,均行TCT检测、HPVL1壳蛋白检测,以宫颈活检病理学结果为“金标准”。比较TCT检测、HPVL1壳蛋白检测、联合检测的结果和诊断效能。结果宫颈活检结果阴性250例,阳性18例,其中10例轻度异型增生(CINⅠ),4例中度异型增生(CINⅡ),3例重度异型增生(CINⅢ),1例宫颈癌(SCC);TCT检测阴性253例,阳性15例;HPVL1壳蛋白检测阴性260例,阳性8例;联合检测阴性246例,阳性22例。联合检测灵敏度高于TCT检测、HPVL1壳蛋白检测(P<0.05);TCT检测、HPVL1壳蛋白检测与联合检测宫颈病变的特异度比较,差异无统计学意义(P>0.05);TCT检测、HPVL1壳蛋白检测与联合检测宫颈病变的准确度比较,差异无统计学意义(P>0.05)。结论TCT+HPVL1壳蛋白检测能提高宫颈病变诊断的灵敏度,有助于临床诊断与治疗。

Objective To study the value of liquid-based thin-layer cytology(TCT)+human papillomavirus L1(HPVL1)chitin detection in the diagnosis of cervical lesions.Methods A total of 268 patients with suspected cervical lesions in our hospital from February 2018 to February 2019 were examined by TCT and HPVL1 capsid protein.The pathological results of cervical biopsy were regarded as the“gold standard”.The results of TCT test,HPVL1 capsid test,combined test and diagnostic efficiency were compared.Results Cervical biopsy results were negative in 250 cases and positive in 18 cases,including 10 cases of CIN I,4 cases of CIN II,3 cases of CIN III and 1 case of SCC;TCT negative in 253 cases,15 cases of positive;HPVL1 negative in 260 cases,8 cases of positive;combined detection negative in 246 cases,22 cases of positive.The sensitivity of combined detection was higher than that of TCT detection,HPVL1 detection(P<0.05).The specificity of TCT detection,HPVL1 detection and the combined detection for cervical lesions was no significant difference(P>0.05).The accuracy of TCT detection,HPVL1 detection and the combined detection for cervical lesions was no significant difference(P>0.05).Conclusion TCT+HPVL1 chitin detection can improve the sensitivity of diagnosis of cervical lesions,and is helpful for clinical diagnosis and treatment.