miRNA与糖尿病心肌病

Study progress of miRNA in diabetic cardiomyopathy

miRNA是一类长约18~25个核苷酸大小的内源性非编码RNA,参与调节转录和转录后基因表达,并调控糖尿病心肌病(DCM)的生理过程.DCM是糖尿病患者慢性不可逆的心脏并发症,主要表现心肌纤维化、心肌细胞肥大、凋亡及微血管病变等,发病机制仍不明确.近年来发现氧化应激、炎症反应与DCM密切相关.本文对miRNA在DCM中的异常表达、发病机制及治疗靶点进行评述,为临床诊治DCM提供依据.

miRNAs are a class of endogenous non-coding RNAs of about 18 to 25 nucleotides in length that regulate transcription and post-transcriptional gene expression and are involved in the regulation of the physiological processes of diabetic cardiomyopathy(DCM).DCM is a chronic irreversible cardiac complication in diabetic patients.The main manifestations include myocardial fibrosis,cardiomyocyte hypertrophy,apoptosis and microvascular disease.The mechanism leading to DCM remains unclear.In recent years,it has been found that oxidative stress and inflammatory response are closely related to DCM.This article intends to provide a new way for the diagnosis and treatment of DCM by briefly describing the new study progress of miRNAs in the abnormal expression,pathogenesis and therapeutic targets of DCM.