卵巢摘除诱导围绝经期综合征动物模型的研究进展

Research advances in animal models of perimenopausal syndrome induced by ovariectomy

围绝经期综合征是由雌激素和孕酮等类固醇激素水平下降引起的一系列症状,严重影响女性的身心健康和生活质量,选择适当的动物模型研究该疾病显得尤为重要。卵巢摘除动物模型常用于围绝经期综合征的研究,包括骨质疏松、记忆下降和认知障碍、焦虑、抑郁、肥胖等。本文通过检索PubMed、中国知网(CNKI)数据库中卵巢摘除动物模型应用于围绝经期综合征的相关文献,对该动物模型应用于围绝经期综合征的研究进展进行了综述。

Perimenopausal syndrome(PMS)is a series of symptoms caused by the decrease of steroid hormone levels,such as estrogen and progesterone,which seriously affect the physical and mental health and quality of life of women.To explore the etiology of the disease,it is important to select the right animal model.The ovariectomy animal model is often used in the study of PMS symptoms,such as osteoporosis,memory and cognitive impairment,anxiety,depression,and obesity.In this paper,research progress of the ovariectomy animal model applied to PMS is reviewed by searching the relevant literature of the ovariectomy animal model in PubMed and CNKI database for PMS.