摘要
可塑性相关基因蛋白(PRG)属于磷脂磷酸酶(LPP)超家族子类,并以亚型特异性模式主要表达于中枢神经系统。PRG通过参与神经元特异性转录调控、蛋白质相互作用以及影响胞内信号通路的转导等途径介入神经系统功能及疾病的发病机制。本文现围绕近年来PRG相关研究的进展综述如下。
Plasticity related gene(PRG)is a subclass of the lipid phosphate phosphatase super family,which is predominantly expressed in the central nervous system in a subtype specific pattern.PRG may be involved in mechanism of nervous system functions and pathogenesis of neuropsychiatric diseases via neuron-specific transcriptional regulation,protein-protein interaction and intracellular signaling pathway regulation.Therefore,this paper reviews the progresses of PRG in recent years and prospects the future research direction.
作者
柳兴凤
肖智
Liu Xingfeng;Xiao Zhi(Guizhou Provincial Key Laboratory of Basic Research in Anesthesia and Organ Protection/Key Laboratory of Brain Science in General Institutes of Higher Education of Guizhou Province,Zunyi Medical University,Zunyi 563000,China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2020年第4期417-421,共5页
Chinese Journal of Neuromedicine
基金
国家自然科学基金(81960217)
贵州省教育厅创新群体重大研究项目(黔教合KY字[2017]043)
遵义医科大学博士科研启动资金项目(F-954)。
关键词
可塑性相关基因
突触可塑性
神经功能
Plasticity-related gene
Synaptic plasticity
Nervous function
