儿童咽喉反流在呼吸道疾病中的分布研究

Study on distribution of children’s laryngopharyngeal reflux in respiratory diseases

目的研究呼吸道疾病患儿中咽喉反流(laryngopharyngeal reflux,LPR)的发生率和分布特征。方法回顾性分析2015年12月至2017年12月就诊于厦门大学附属第一医院儿科呼吸专科的常规治疗效果欠佳的97例呼吸道疾病患儿的临床资料,对所有患儿进行24 h咽喉pH监测。对数据结果采用SPSS20统计软件进行分析。结果(1)97例患儿中LPR检出率为55.67%(54/97)。(2)LPR患儿有咳嗽、喘息、喉中痰鸣、流涕、鼻塞、清嗓等临床症状。初步诊断包括肺炎、变应性鼻炎及鼻窦炎、哮喘、慢性咳嗽、气管软化等。(3)不同呼吸道疾病中LPR检出率差异有统计学意义(χ^2=9.107,P=0.011),其中肺炎患儿高于哮喘未控制患儿(χ^2=7.583,P=0.006),哮喘未控制患儿高于气管软化患儿(χ^2=4.44,P=0.035)。结论LPR在呼吸道疾病患儿中检出率较高,但其临床表现多样,无特异性,应提高对呼吸道疾病患儿LPR的关注。

Objective To study the morbidity and distribution characteristics of laryngopharyngeal reflux in respiratory diseases.Method To review and analyze the clinical data of 97 children with poor routine treatment in pediatric respiratory specialty of the first affiliated hospital of Xiamen University from December 2015 to December 2017,and to monitor the throat pH 24h all children.Analysis using SPSS20 statistical software.Result(1)Finally,97 patients were included,and the detection rate of LPR was 55.67%.(2)The clinical symptoms of children with laryngopharyngeal reflux were as follows:cough,wheezing,phlegm sound,runny nose,stuffy nose and clear mulberryal.Initial diagnoses included pneumonia,allergic rhinitis and sinusitis,asthma,chronic cough,tracheomalacia,et al.(3)There was a statistically significant difference in the detection rate of laryngopharyngeal reflux in different respiratory diseases(χ^2=9.107,P=0.011).The detection rate in the pneumonia group was higher than that in the asthma group(χ^2=7.583,P=0.006),and the asthma group was higher than the tracheomalacia group(χ^2=4.44,P=0.035).Conclusion The detection rate of children’s laryngopharyngeal reflux in children’s respiratory diseases is high.The clinical manifestations are diverse and non-specific.Clinical attention should be paid to LPR of children with respiratory diseases.