多维评估在儿童难治性哮喘中的作用

Role of multidimensional assessment in refractory asthma of children

在哮喘规范化诊治的推广过程中,难治性哮喘是儿科医师绕不开的临床难题。现首先强调多维评估在诊断难治性哮喘中的重要作用,再详细介绍多维评估的方法,并系统综述近年国内外对真正难治性哮喘内在机制的研究,展示难治性哮喘内表型、生物标志物、靶向治疗方法等研究进展,以期开拓临床医师的思路,以精准医疗为目标,进一步提升哮喘的诊治水平。

Refractory asthma is an inevitable clinical difficulty that is often faced by pediatricians in the promotion of standardized diagnosis and treatment of asthma.In this paper,the important role of multidimensional assessment(MDA)in the diagnosis of refractory asthma is emphasized,and the method of MDA is described in detail at first.Then foreign and domestic research on the internal mechanism of truly refractory asthma in recent years is syste-matically reviewed,which shows the progress of research on the internal phenotypes,biomarkers and targeted treatment of refractory asthma to the readers,with a view to developing the pediatricians′ideas and further improving the diagnosis and treatment level of asthma by taking precision medical treatment as the goal.