摘要
高迁移率族蛋白B1作为一种表达于真核细胞核的非组蛋白,释放到细胞外后可促进炎症反应,参与细胞因子的正反馈环,与多种自身免疫性及炎症性疾病的发病机制密切相关。近年来的研究发现其可能成为紫癜性肾炎、狼疮性肾炎的血清标志物,并对幼年特发性关节炎预后及川崎病患儿对静脉丙种球蛋白无反应可能具有一定预示作用。
High mobility group box 1 is a kind of non-histone protein which expressed in the nucleus of eukaryotic cells.Which can promote inflammatory reaction and participate in the positive feedback loop of the production of cytokines after translocated outside the cells.As a result,it′s closely related to the pathogenesis of various autoimmune and inflammatory diseases.Recent studies have revealed that high mobility group box 1 may serve as a serum marker of Henoch-Sch?nlein purpura nephritis and lupus nephritis,and a predicator of the prognosis of juvenile idiopathic arthritis and intravenous immunoglobulin resistance in Kawasaki disease.
作者
阮小霞
唐雪梅
Ruan Xiaoxia;Tang Xuemei(Department of Rheumatology and Immunology,Children′s Hospital of Chongqing Medical University,Ministry of Education Key Laboratory of Child Development and Disorder,China International Science and Technology Cooperation Base of Child Development and Critical Disorders,Chongqing Key Laboratory of Child Infection and Immunity,Chongqing 400014,China)
出处
《中华实用儿科临床杂志》
CSCD
北大核心
2020年第5期398-400,共3页
Chinese Journal of Applied Clinical Pediatrics
