抑瘤汤联合热疗治疗恶性肿瘤骨转移疼痛

Yiliu Decoction Combined with Hyperthermia Therapy in Treating Bone Metastases Induced Pain of Malignant Tumors

目的:观察抑瘤汤联合热疗干预恶性肿瘤骨转移患者疼痛的临床疗效。方法:将106例恶性肿瘤骨转移患者,按随机数字法分为观察者54例,对照组52例,所有患者均达到世界卫生组织(WHO)疼痛强度分级标准的中度或重度疼痛。对照组给予盐酸羟考酮缓释片干预疼痛,观察组在对照组治疗基础上给予抑瘤汤联合热疗。14 d后比较两组患者镇痛疗效、生活质量、盐酸羟考酮缓释片日均用量、炎症因子水平及不良反应。结果:观察组镇痛有效率为70.4%,对照组为48.1%,两组比较,差异有统计学意义(P<0.05)。观察组生活质量的有效率为74.1%,对照组为55.8%,两组比较,差异有统计学意义(P<0.05)。观察组盐酸羟考酮缓释片日均用量、炎症因子水平(白细胞介素6、肿瘤坏死因子-α)显著低于对照组,两组比较,差异均有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异均无统计学意义(P>0.05)。结论:抑瘤汤联合热疗干预恶性肿瘤骨转移疼痛效果显著,可提高患者生活质量,降低盐酸羟考酮缓释片日均用量、炎症因子水平。

Objective: To observe the clinical effect of Yiliu Decoction combined with hyperthermia therapy on pain in patients with bone metastases from malignant tumors. Methods: 106 patients with bone metastases from malignant tumors were randomly divided into 2 groups according to the random number method. There were 54 observers and 52 controls. All patients achieved moderate or severe pain according to the World Health Organization( WHO) pain intensity classification standard.. The control group was given oxycodone hydrochloride sustained-release tablets to prevent pain,and the observation group was given Yiliu Decoction combined with hyperthermia on the basis of the treatment of the control group. After 14 days,the analgesic efficacy,quality of life,average daily dosage of oxycodone hydrochloride sustained-release tablets,inflammatory factor levels,and adverse reactions were compared between the two groups. Results: The effective rate of analgesia was 70. 4% in the observation group and 48. 1% in the control group. The difference between the two groups was statistically significant( P < 0. 05). The effective rate of quality of life in the observation group was 74. 1% and that in the control group was 55. 8%. The difference between the two groups was statistically significant( P < 0. 05). The average daily dosage of oxycodone hydrochloride sustained-release tablets and the levels of inflammatory factors( interleukin 6,tumor necrosis factor-α) in the observation group were significantly lower than those in the control group. The differences between the two groups were statistically significant( P < 0. 05). There was no significant difference in the incidence of adverse reactions between the two groups of patients( P > 0. 05). Conclusion: Yiliu Decoction combined with hyperthermia therapy has a significant effect on the pain of malignant tumor bone metastasis,which can improve the quality of life of patients,reduce the daily dosage of oxycodone sustained-release tablets,and the level of inflammatory factors.