中医治疗肝纤维化组方规律

Formulas Law of TCM in Treating Liver Fibrosis

目的:基于中医传承辅助平台系统软件,分析中药方剂组方规律并进行整理和数据挖掘,为中医药临床靶向治疗肝纤维化提供依据。方法:筛选中国知网文献数据库中2009年1月至2019年1月期间中医药治疗肝纤维化的中药方剂106首,药物208味。并将方剂录入中医传承辅助系统(V2.5版本)以建立方剂数据库,采用软件集成关联规则apriori算法、复杂系统熵聚类、无监督的熵层次聚类等数据挖掘方法,对筛选出的方剂进行相关分析得出单味药物应用频次、药对组合频次、四气、五味、归经、用于新方聚类的核心组合及新处方。结果:对筛选出的106首治疗肝纤维化中药方剂进行分析,确定在常用的单味药物有丹参、黄芪、鳖甲等;基于复杂网络发现的核心组合有丹参-黄芪-赤芍;丹参-鳖甲-赤芍;黄芪-当归-柴胡等;其中用药性以温、平、寒为主;处方药物多具苦、甘、辛性,归经以肝经为主;基于熵层次聚类新处方有7个。结论:表明通过中医传承辅助平台挖掘方剂数据进行录入、管理、查询及分析,能够可实现对方剂数据录入、管理、查询和分析,发现近代医家治疗肝纤维化以"补虚、泄实"为主,中药治法以活血化瘀、疏肝健脾、清热(解毒)利湿等为主,其常与扶正补虚等其他治法配合使用。

Objective: Based on the software of traditional Chinese medicine inheritance platform system,analyze the formula of Chinese medicine prescriptions and sort out and data mining,so as to provide basis for clinical targeted treatment of liver fibrosis in traditional Chinese medicine. Methods: A total of 106 traditional Chinese medicine prescriptions for treating liver fibrosis from January 2009 to January 2019 were screened from the China Knowledge Base Literature Database,with 208 flavors of medicine. The prescription was entered into the traditional Chinese medicine inheritance auxiliary system( V2. 5 version) to establish a prescription database. Data integration methods such as software integration association rule apriori algorithm,complex system entropy clustering,and unsupervised entropy hierarchical clustering were used to screen out the prescription Correlation analysis was performed to obtain the frequency of single-drug application,the frequency of drug pair combinations,Siqi,Wuwei,Guijing,core combinations used in Xinfang clustering,and new prescriptions. Results: The 106 selected traditional Chinese medicine prescriptions for treating liver fibrosis were analyzed,and it was determined that the commonly used single-flavor drugs are Danshen,Astragalus and Biejia,etc.;the core combination found based on complex networks is Danshen( salvia miltiorrhiza),Huangqi( astragalus) and Biejia( turtle shell);The core combinations found based on complex networks are Danshen( Salvia miltiorrhiza)-Huangqi( astragalus)-Chishao( root of common peony) and Huangqi( astragalus)-Danggui( angelica sinensis)-Chaihu( radix bupleuri) etc.;The medicinal properties of them are mainly Warm,Ping,and Cold;the prescription drugs are mostly bitter,sweet,and astringent,and Guijing character are mainly to Liver. There are 7 new prescriptions clustering based on entropy hierarchy. Conclusion: Through the traditional Chinese medicine inheritance auxiliary platform mining prescription data for input,management,query and analysis,it is possible to achieve data entry,management,query and analysis of other prescription data. It is found that modern doctors treat liver fibrosis mainly with "Hua Xu Xie Shi"method,and the traditional Chinese medicine treatment methods are mainly activating blood circulation,removing stasis,relieving Liver Qi and tonifying Spleen,clearing Heat( detoxifying) and dispeling dampness,etc.,which are often used in conjunction with other treatment methods of strengthening Zheng Qi and and tonifying deficiency.