降脂通脉胶囊联合藻酸双酯钠治疗高脂血症的临床研究

Clinical study on Jiangzhi Tongmai Capsules combined with sodium alginate diester in treatment of hyperlipidemia

目的探讨降脂通脉胶囊联合藻酸双酯钠片治疗高脂血症的临床疗效。方法选择2018年3月-2019年3月在陕西省荣誉军人康复医院治疗的高脂血症患者86例,根据用药的差别分为对照组(43例)和治疗组(43例)。对照组口服藻酸双酯钠片,50mg/次,3次/d;治疗组在对照组基础上口服降脂通脉胶囊,2.0g/次,3次/d。两组患者经4周治疗。观察两组患者临床疗效,同时比较治疗前后两组患者高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、胆固醇(TC)、嗜酸性粒细胞阳离子蛋白(ECP)、摄食抑制因子-1(NSF-1)、硫氧还蛋白相互作用蛋白(TXNIP)、肿瘤坏死因子-α(TFN-α)、白细胞介素-1β(IL-1β)、脂联素(ADP)、超氧化物歧化酶(SOD)、丙二醛(MDA)和谷胱甘肽过氧化物酶(GSH-Px)水平。结果治疗后,对照组临床有效率为81.40%,显著低于治疗组的97.67%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者TC、TG、LDL-C、ECP、IL-1β、TFN-α、TXNIP、NSF-1和MDA水平均显著降低(P<0.05),而HDL-C、ADP、SOD和GSH-Px水平均显著升高(P<0.05),且治疗组患者这些指标明显好于对照组(P<0.05)。结论降脂通脉胶囊联合藻酸双酯钠片治疗高脂血症可有效降低血脂指标,促进机体细胞因子和氧化应激指标的改善,具有一定的临床推广应用价值。

Objective To explore the clinical effect of Jiangzhi Tongmai Capsules combined with sodium alginate diester in treatment of hyperlipidemia. Methods Patients(86 cases) with hyperlipidemia in Shaanxi Rongjun Rehabilitation Hospital from March 2018 to March 2019 were divided into control(43 cases) and treatment(43 cases) groups based on different treatments. Patients in the control group were po administered with Sodium Alginate Diester Tablets, 50 mg/time, three times daily. Patients in the treatment group were po administered with Jiangzhi Tongmai Capsules on the basis of the control group, 2 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the levels of TC, TG, LDL-C, HDL-C, ECP, IL-1β, TFN-α, TXNIP, NSF-1, SOD, GSH-Px and MDA in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 81.40%, which was significantly lower than 97.67% in the treatment group, and there were differences between two groups(P<0.05). After treatment, the levels of TC, TG, LDL-C, ECP, IL-1β, TFN-α, TXNIP, NSF-1 and MDA in two groups were significantly decreased(P<0.05), but the HDL-C, ADP, SOD and GSH-Px levels were significantly increased(P<0.05), and these indexes in the treatment group were significantly better than those in the control group(P<0.05). Conclusion Jiangzhi Tongmai Capsules combined with sodium alginate diester in treatment of hyperlipidemia can effectively reduce blood lipid level, promote the improvement of cytokines and oxidative stress, which has a certain clinical application value.