中医药抗肝硬化作用机制的研究进展

Research Progress in Mechanism of Chinese Medicine against Liver Cirrhosis

中医药因具有改善临床症状、有助于胶原蛋白降解、减轻肝细胞炎症、提高生活质量等优势,在慢性肝病的临床治疗中应用越来越广泛。肝硬化是各种慢性肝病进展的最终结局。肝硬化终末期可出现肝衰竭、上消化道出血、腹水、肝性脑病、肝癌等并发症,严重威胁患者生存期和生存质量,所以逆转、减缓肝纤维化进展,控制肝硬化进程,是慢性肝病防治的重点之一。目前,现代医学抗肝硬化的方法主要为去除病因和肝移植;近年来,中医药成为治疗肝硬化的重要手段之一。但中医药在抗肝纤维化、肝硬化中的具体机制仍有待进一步研究。

Traditional Chinese medicine has become more and more widely used in clinical treatment of chronic liver diseases because of its advantages in improving clinical symptoms,helping collagen degradation,reducing inflammation of liver cells and improving quality of life.Cirrhosis is the final outcome of the progression of various chronic liver diseases.Complications such as liver failure,upper gastrointestinal hemorrhage,ascites,hepatic encephalopathy and liver cancer may occur in the end-stage of liver cirrhosis,which seriously threaten the survival period and quality of life of the patients.Therefore,reversing and slowing down the progress of liver fibrosis and controlling the progress of liver cirrhosis is one of the key points in the prevention and treatment of chronic liver diseases.At present,the main anti-cirrhosis methods in modern medicine are removing the etiology and liver transplantation.In recent years,traditional Chinese medicine has become one of the most important methods to treat liver cirrhosis,however,the specific anti-fibrosis and anti-cirrhosis mechanisms remain to be further studied.