氧气驱动雾化吸入联合呼吸机对急性心力衰竭的救治效果及血气指标炎症因子的影响

Effect of Oxygen Driven Atomization Inhalation Combined with Ventilator on Acute Heart Failure and the Influence of Blood Gas Index and Inflammatory Factors

目的:探讨氧气驱动雾化吸入联合呼吸机对急性心力衰竭的救治效果及血气指标、炎症因子的影响。方法:选择我院2016年1月至2019年1月收治的65例急性心力衰竭患者,通过简单随机数表法分为观察组(35例)和对照组(30例),在常规治疗基础上,对照组给予无创呼吸机治疗,观察组联合氧气驱动雾化吸入治疗,均连续治疗7d。比较两组临床疗效、血气指标、炎症因子、心功能指标的变化及不良反应。结果:治疗后,观察组临床疗效总有效率明显比对照组高(P<0.05);两组血气指标动脉二氧化碳分压(PaCO2)、动脉血氧分压(PaO2)及动脉血氧饱和度(SaO2),炎症因子高敏C反应蛋白(hs-CRP)、白介素-6(IL-6),心功能指标:N端前脑钠肽(NT-proBNP)、心率(HR)、每搏输出量(SV)、左室射血分数(LVEF)组间、不同时间点比较差异有统计学意义(P<0.05),且上述指标在组间、不同时间点具有交互作用(P<0.05),观察组治疗前后差值均大于对照组(P<0.05);两组不良反应比较差异无统计学意义(P>0.05)。结论:氧气驱动雾化吸入联合呼吸机对急性心力衰竭的救治效果显著,可有效改善血气指标、炎症因子的表达,促进心功能恢复,安全性好,值得应用推广。

Objective:To study the rescue effect oxygen-driven nebulization inhalation combined with ventilator on blood gas index and inflammatory factors in patients with acute heart failure.Methods:65 patients of chronic renal failure were divided into 35 cases in the observation group,from January 2016 to January 2019 in our hospital.The 30 cases in the control group by the simple random number table,On the basis of routine treatment,the control group was treated with non-invasive ventilator,while the observation group was combined with oxygen-driven nebulization inhalation,they continuous treatment for 7 days.The clinical efficacy,the changes of blood gas index,inflammatory factors,cardiac function index and adverse reactions were compared between the two groups.Results:After treatment,the total effective rate of the observation group was significantly higher than the control group(P<0.05).The blood gas indexe arterial partial pressure of carbon dioxide(PaCO2),arterial partial pressure of oxygen(PaO2),arterial oxygen saturation(SaO2),inflammatory factor high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),cardiac function index N-terminal pro-brain natriuretic peptide(NT-proBNP),heart rate(HR),stroke volume(SV),left ventricular ejection fraction(LVEF)of the two groups,there were significant differences between groups and at interblock and different time points(P<0.05);The above indicators have interaction among interblock and different time points(P<0.05);The difference before and after treatment in the observation group was greater than the control group(P<0.05);There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:Oxygen-driven nebulization inhalation combined with ventilator is well for acute heart failure,which can effectively improveimprove the expression of blood gas indicators and inflammatory factors,promote the recovery of cardiac function,and has good safety,it's worthy of application and promotion.