2型糖尿病患者血清炎症因子水平与心脑血管病变的相关性分析

Analysis on Correlation between Inflammatory Cytokines in Type 2 Diabetes Mellitus and Cardiovascular and Cerebrovascular Diseases

目的:探讨2型糖尿病患者血清炎症因子水平与心脑血管病变的相关性。方法:选择2018年1月至2019年4月我院内科收治的2型糖尿病患者114例,按患者实际心脑血管病症合并状况分为未合并组和合并组,每组57例,另选择同期医院门诊健康体检人员设为健康组57例,对所有入选人员进行颈动脉超声检查,了解病变状况,并采血检测肿瘤坏死因子-α、C反应蛋白、可溶性细胞间黏附分子-1、可溶性血管细胞黏附分子-1、单核细胞趋化蛋白水平,分析总结检测结果。结果:健康组、未合并组、合并组患者的颈动脉内膜增厚、颈动脉粥样硬化斑块形成、颈动脉狭窄检出率组间对比均呈逐渐升高趋势,且差异有统计学意义(P<0.05)。健康组、未合并组、合并组患者的肿瘤坏死因子-α、C反应蛋白、可溶性细胞间黏附分子-1、可溶性血管细胞黏附分子-1、单核细胞趋化蛋白水平组间对比均呈逐渐升高趋势,且差异有统计学意义(P<0.05)。结论:2型糖尿病炎症因子水平与心脑血管病变之间存在相关性,炎性因子是2型糖尿病患者合并心脑血管病变的危险因素。

Objective:To investigate the correlation between inflammatory cytokines in type 2 diabetes and cardiovascular and cerebrovascular diseases.Methods:From January 2018 to April 2019,114 patients with type 2 diabetes admitted to our hospital were divided into two groups:the non combined group and the combined group,with 57 cases in each group.In addition,57 outpatients were selected as the healthy group,All the selected persons were examined by carotid ultrasound to understand the pathological changes,and the levels of TNF-α,C-reactive protein,soluble intercellular adhesion molecule-1,soluble vascular cell adhesion molecule-1 and monocyte chemoattractant protein were detected by blood sampling.The results were analyzed and summarized.Results:The carotid intima thickening,the formation of carotid atherosclerotic plaque and the detection rate of carotid stenosis in the healthy group,the non combined group and the combined group were all gradually increased(P<0.05).The levels of TNF-α,C-reactive protein,soluble intercellular adhesion molecule-1,soluble vascular cell adhesion molecule-1 and monocyte chemoattractant protein in the healthy group,the non combined group and the combined group were gradually increased,and the difference was statistically significant(P<0.05).Conclusion:There is a correlation between the levels of inflammatory factors and cardiovascular and cerebrovascular diseases in type 2 diabetes.Inflammatory factors are risk factors for cardiovascular and cerebrovascular diseases in patients with type 2 diabetes.