氯雷他定辅助治疗小儿咳嗽变异性哮喘的效果及对患儿肺功能的影响

Effect of loratadine on cough variant asthma in children and its influence on pulmonary function

目的观察氯雷他定辅助治疗小儿咳嗽变异性哮喘(CVA)的效果及对患儿肺功能的影响。方法选取2017年8月至2018年8月本院收治的小儿咳嗽变异性哮喘患儿66例作为研究对象,采用随机数字法分为常规组(n=33)和联合治疗组(n=33)。常规组单用酮替芬治疗,联合治疗组在常规组治疗的基础上采用氯雷他定辅助治疗。观察两组患儿肺功能指标[呼气高峰流量(PEFR)、用力肺活量(FVC)、1 s用力呼气量(FEV1)]水平变化、临床总有效率和复发率。结果治疗后,联合治疗组PEFR(5.55±0.14)L/s、FVC(2.41±0.38)L、FEV1(2.73±0.25)L较治疗前均明显升高(P<0.05),且明显高于常规组(P<0.05);联合治疗组临床总有效率为93.94%,明显高于常规组(P<0.05);联合治疗组复发率为3.03%,明显低于常规组(P<0.05)。结论氯雷他定辅助治疗小儿咳嗽变异性哮喘的效果更显著,值得临床推广。

Objective To observe the effect of loratadine on cough variant asthma(CVA)in children and its influence on pulmonary function.Methods 66 children with cough variant asthma received and treated in our hospital from August 2017 to August 2018,which were randomly divided into routine group(n=33)and combined treatment group(n=33).The routine group was treated with ketotifen,the combined treatment group was treated with loratadine on the basis of routine group.The changes of pulmonary function index(PEFR,FVC,FEV1)level,clinical total effective rate and recurrence probability were observed in two the groups.Results After treatment,the levels of PEFR(5.55±0.14)L/s,FVC(2.41±0.38)L and FEV1(2.73±0.25)L in the combined treatment group were significantly higher than those before treatment(P<0.05),and higher than the routine group(P<0.05).The total clinical effective rate in the combined treatment group was 93.94%,significantly higher than that in the routine group(P<0.05).The recurrence rate of the combined treatment group was 3.03%,which was significantly lower than that of the routine group(P<0.05).Conclusion The effect of loratadine in the adjuvant treatment of cough variant asthma in children is more significant,which can be widely used in clinic.