髋关节手术术后谵妄相关脑脊液生物标志物的研究进展

Research progress in cerebrospinal fluid biomarkers associated with postoperative delirium after hip fracture surgery

髋关节手术后的老年患者是发生术后谵妄(postoperative delirium,POD)的高危人群,目前POD发病机制尚未明确,对脑脊液生物标志物的分析可有助于对其病理生理机制的理解。文章回顾了近年来髋关节手术POD相关脑脊液生物标志物的文献,以POD危险标志物、POD活性标志物和POD终产物为特点进行分类,为探索POD发生的病理生理机制提供线索,为预防、诊断和治疗POD提供依据。

Elderly patients undergoing hip fracture surgery have high risk to develop postoperative delirium(POD).At present,the pathophysiological mechanism of POD is unclear,and research on cerebrospinal fluid(CSF)biomarkers is helpful to elucidate the pathophysiological mechanism of POD.This paper reviews the literature concerning CSF biomarkers associated with POD after hip frac-ture surgery,where the CSF biomarkers were classified based on the features of POD risk markers,POD active markers and POD end products.This paper will provide evidence for investigation of the pathophysiological mechanism of POD and for prevention,diagnosis and treatment of POD.