摘要
慢性肝脏损伤将导致肝纤维化,不及时诊断治疗易进一步发展为肝硬化等更严重的肝脏疾病。近年来,荧光成像及光谱分析技术以其快速、简便、无损等优势,极大地推进了肝纤维化疾病的检测和研究,具有良好的发展前景。重点综述了目前荧光成像及光谱分析技术在肝纤维化组织、细胞以及分子机制研究中的最新成果,并展望了其研究难点和潜在应用前景。
Chronic liver injury induces liver fibrosis that must be diagnosed and treated within an appropriate timeframe.Otherwise,it can easily evolve into liver cirrhosis,or other more severe liver diseases.In recent years,fluorescence imaging and spectral analysis techniques have greatly promoted the detection and research of liver fibrosis diseases because they offer rapid,simple,and non-instrusive detection,and thus have great potential.This review highlights the latest achievements of fluorescence imaging and spectral analysis techniques in the investigation of tissue,cell,and molecular mechanisms of liver fibrosis.The research difficulties and potential application prospects of the technique regarding liver fibrosis are also discussed.
作者
林雅婷
许建树
谢树森
林居强
Lin Yating;Xu Jianshu;Xie Shusen;Lin Juqiang(Key Laboratory of Opto-Electronic Science and Technology for Medicine(Ministry of Education),Key Laboratory of Photonic Technology of Fujian Province,College of Photonic and Electronic Engineering,Fujian Normal University,Fuzhou,Fujian 350007,China)
出处
《激光与光电子学进展》
CSCD
北大核心
2020年第1期14-26,共13页
Laser & Optoelectronics Progress
基金
国家重点基础研究发展计划(2015CB352006)
国家自然科学基金(61775037)
福建省自然科学基金(2019J01270)。
关键词
图像处理
肝纤维化
荧光成像
光谱分析
检测
image processing
liver fibrosis
fluorescence imaging
spectral analysis
detection
