酸枣仁汤联合丙戊酸钠治疗外伤性癫痫的临床疗效分析

Clinical efficacy analysis of Semen ziziphi spinosae decoction combined Sodium valproate sustained-release tablets on treating post-traumatic epilepsy

目的通过使用酸枣仁汤联合丙戊酸钠(Sodium valproate,VPA)治疗外伤性癫痫(Post-traumatic epilepsy,PTE)患者,观察其抗癫痫治疗效果。方法收集昆山市中医医院癫痫专科2017年1月-2019年1月收治的PTE患者30例,年龄31~75岁,平均(42.5±13.5)岁。男性16例,女性14例,随机分为试验组(酸枣仁汤+VPA,n=15)和对照组(VPA,n=15),记录患者一般情况、影像学资料和脑电图资料。定期随访9个月,分析并比较治疗效果。结果酸枣仁汤联合VPA抗癫痫治疗9个月后,患者的PTE发病率明显较VPA单药治疗显著降低,患者一般情况、影像学和脑电图资料,差异无统计学意义(P<0.01)。结论口服酸枣仁汤联合VPA对PTE患者的抗癫痫9个月有治疗效果,且酸枣仁汤联合VPA组有效率为93.3%,高于VAP组80%,为临床诊治提供一定的参考意义。

Objective Determine the effect of Semen ziziphi spinosae decoction combined Sodium valproate(VPA)sustained-release tablets on treating patients with Post-traumatic epilepsy(PTE).Methods 30 patients are chosen among the patients who were hospitalised in Epilepsy Department of Kunshan Traditional Chinese Medicine Hospital from Jan 2017 to Jan 2019.The age ranges from 31 to 75,averaging at(42.5±13.5)years old,and composed of 16 male samples and 14 female,randomly divided into experimental group(Semen ziziphi spinosae decoction combined VPA,n=15)and control group(VPA,n=15).In general,imaging data and EEG data are collected.Regular follow-up is also carried out for these 30 patients.The results are analysed to determine the effect of treatment.Results After 9-months treatment of Semen ziziphi spinosae decoction combined VPA,morbidity of experiment group is significantly lower than that of the control group.It is also found that the differenes of imaging data and EEG data of patients were of no statistical significance.Conclusion It is demonstrated that Semen ziziphi spinosae decoction combined VPA has superior performance in treating patients with PTE.The efficiency of Semen ziziphi spinosae decoction combined VPS in treating PTE is 93.3%,higher than the 80%of VPA.It can serve as reference for clinical diagnosis and treatment.