急性基底节出血患者SF、OPN、cFN水平分布特征及预后价值分析

An analysis towards the effect of serum SF,OPN and cFN levels on prognosis in patients with acute basal ganglia hemorrhage

目的对急性基底节出血患者血清铁蛋白(SF)、骨桥蛋白(OPN)及细胞纤维连接蛋白(cFN)水平分布特征进行分析,并讨论其对预后的影响。方法选取2015年1月至2016年6月该院急性基底节出血患者50例作为急性基底节出血组,同期就诊的其他类型急性脑出血患者68例作为对照组。收集两组受试对象一般情况,采用酶联免疫吸附法(ELISA)检测血清中SF、OPN及cFN水平,并嘱患者在出院2年后进行入院随访;研究分析急性基底节出血患者SF、OPN及cFN水平分布特征,并讨论其对随访不良预后的影响作用。结果急性基底节出血组SF水平为(44.28±2.47)μg/L、OPN水平为(12.03±3.66)ng/mL,cFN水平为(3.22±0.70)ng/mL,均高于对照组,差异有统计学意义(P<0.05)。急性基底节出血组预后不良患者中SF、OPN及cFN水平异常的例数均显著多于正常的例数,差异均有统计学意义(P<0.05);生存分析曲线结果显示,SF、OPN及cFN高水平患者出现预后不良事件(死亡、神经功能中度缺损)的时间普遍提前。结论急性基底节出血患者的SF、OPN及cFN水平与病情和预后存在关联,可在临床上指导患者诊疗。

Objective To analyze the distribution characteristics of serum ferritin(SF),osteopontin(OPN)and cellular fibronectin(cFN)levels in patients with acute basal ganglia hemorrhage and to discuss their effects on prognosis.Methods 50 patients with acute basal ganglia hemorrhage in a hospital from January 2015 to June 2016 were selected as the acute basal ganglia hemorrhage group,and 68 patients with other types of acute cerebral hemorrhage in the same period were selected as the control group.The general conditions of the two groups were collected.The levels of SF,OPN and cFN in serum were detected by enzyme-linked immunosorbent assay(ELISA).The patients were followed up for 2 years after discharge.The serum SF of patients with acute basal ganglia hemorrhage was analyzed.The horizontal,OPN,and cFN levels were characterized and their effects on poor prognosis were followed.Results The SF level in the acute basal ganglia hemorrhage group was(44.28±2.47)μg/L,the OPN level was(12.03±3.66)ng/mL,and the cFN level was(3.22±0.70)ng/mL,all of which were higher than the control group,with statistically significant differences(P<0.05).The number of patients with abnormal SF,OPN and cFN levels in the acute basal ganglia hemorrhage group with poor prognosis was significantly higher than that of the normal patients,and the differences were statistically significant(P<0.05).The results of survival analysis curve showed that patients with high SF,OPN and cFN levels generally had earlier time of adverse prognostic events(death,moderate neurological impairment).Conclusion Patients with SF,OPN and cFN levels are associated with the condition and prognosis of patients with acute basal ganglia hemorrhage,and can guide patients in clinical diagnosis and treatment.