姜黄素膜运载体系的构建及功能性应用研究进展

Recent Progress in the Construction and Functional Application of Curcumin Membrane Delivery Systems

姜黄素因具有多种生物活性而获得广泛的研究关注,但由于其低水溶性和生理转运过程中的生化/结构降解,导致其生物利用度低下,制约其经济价值。因此,大量以姜黄素为基础的药物递送系统被引入,其中,将姜黄素纳入以生物聚合物为基础的膜运载体系被认为具有广阔的发展前景。多糖、蛋白质等都是经过广泛研究的聚合物载体,能够用于输送多种生物活性天然化合物。本文对姜黄素分子递送过程中存在的挑战以及构建姜黄素膜运载体系的研究进展进行概述,着重阐述姜黄素膜运载体系在食品抗氧化包装、新鲜度监测以及抗菌保鲜等方面的应用,旨在为姜黄素的进一步开发与应用提供理论参考。

Curcumin has attracted extensive research attention due to its various biological activities. However, its low water solubility and biochemical/structural degradation during physiological transport lead to a low bioavailability which largely limits its economic value. Therefore, a large number of curcumin-based drug delivery systems have been introduced. The inclusion of curcumin into a biopolymer-based membrane delivery system is considered to have broad prospects. Polysaccharides and proteins are widely used as the polymeric carriers for the delivery of a variety of biologically active natural compounds. In this article, the challenges in the process of curcumin delivery and the recent progress in the construction of curcumin membrane delivery systems are summarized. Special focus is placed on reviewing the application of curcumin membrane delivery systems in food antioxidant packaging, freshness monitoring and antibacterial preservation, aiming to provide a theoretical basis for further development and application of curcumin.