地尔硫卓联合美托洛尔治疗冠心病不稳定型心绞痛的效果以及对血脂和运动耐力的影响

Effect of Diltiazem Combined with Metoprolol on Unstable Angina Pectoris of Coronary Heart Disease and Its Effect on Blood Lipids and Exercise Endurance

目的探讨地尔硫卓联合美托洛尔对冠心病不稳定型心绞痛患者的疗效及对血脂和运动耐力的影响。方法回顾性分析2017年1月—2019年1月就诊的冠心病不稳定型心绞痛患者120例的临床资料。根据治疗方案不同分为对照组和观察组,每组60例。对照组给予美托洛尔治疗,观察组给予地尔硫卓联合美托洛尔治疗。比较2组的治疗总有效率,比较治疗前后心绞痛发生情况、左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)水平,并观察2组的运动耐力和不良反应情况。结果观察组的治疗总有效率高于对照组,6 min步行距离长于对照组(P<0.05)。治疗后,2组的心绞痛发作次数、持续时间、LVEDD、LVESD、TC、LDL-C、TG水平均低于治疗前,且观察组低于对照组(P<0.05)。治疗后,2组的LVEF、HDL-C水平高于治疗前,且观察组高于对照组(P<0.05)。2组的不良反应发生率比较差异无统计学意义(P>0.05)。结论地尔硫卓联合美托洛尔可减少冠心病不稳定型心绞痛患者心绞痛发作次数和持续时间,同时改善心功能和血脂指标,提高运动耐力和治疗总有效率。

Objective To explore the effect of Diltiazem combined with Metoprolol on patients with unstable angina pectoris of coronary heart disease(CHD)and the influence on blood lipid and exercise endurance.Methods The clinical data of 120 patients with unstable angina pectoris of CHD who were treated from January 2017 to January 2019 were retrospectively analyzed.The patients were divided into control group and observation group according to different treatment plans,with 60 cases in each group.The control group was treated with Metoprolol,while the observation group was treated with Diltiazem combined with Metoprolol.Total effective rate of treatment in the two groups were compared,and incidence of angina pectoris,left ventricular end systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),and triglyceride(TG)levels before and after the treatment were compared.Exercise endurance and adverse reactions in both groups were observed.Results The total effective rate in the observation group was higher than that in the control group,and the 6-min walking distance was longer than that in the control group(P<0.05).After treatment,the angina attack frequency,duration,LVEDD,LVESD,TC,LDL-C and TG levels in the two groups were lower than those before treatment,which were lower in the observation group than in the control group(P<0.05).After treatment,LVEF and HDL-C levels in both groups were higher than those before treatment,which were higher in the observation group than in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Diltiazem combined with Metoprolol can reduce the frequency and duration of unstable angina pectoris in patients with unstable angina pectoris of CHD,and improve cardiac function,blood lipid index,exercise endurance and total effective rate.