部队人群肺结核感染危险因素Meta分析

Meta-analysis of Risk Factors of Pulmonary Tuberculosis in Chinese Military Population

目的了解部队肺结核发病的危险因素,以采取针对性地预防控制措施,为今后的防治工作提供依据。方法检索有关部队肺结核感染的研究文献报告,提取文献数据并建立数据库,对研究文献进行整理,进行Meta分析。结果单因素分析合并比值比(OR)及其95%CI分别为:肺结核病例接触史1.498(1.387,1.619)、卡介苗接种史0.736(0.594,0.912)、卡痕0.608(0.415,0.891)、劳动训练强度1.642(1.310,2.058)、住房类别0.752(0.647,0.874)、入伍地类别1.252(1.139,1.376)、体质指数0.870(0.818,0.925)、吸烟1.292(1.174,1.422);多因素合并分析合并OR及其95%CI分别为:劳动训练强度1.254(1.126,1.397)、住房类别0.657(0.524,0.824)、肺结核病例接触史1.617(1.457,1.795)、卡介苗接种史0.786(0.614,1.008)、吸烟1.331(1.141,1.553)、人际交往1.427(1.237,1.646)。除了多因素分析中的卡介苗接种史外其他均有统计学意义(P<0.01)。结论单因素分析中体质指数正常、住房类型为楼房、卡介苗接种史、有卡痕为保护因素,劳动训练强度重度、有肺结核病例接触史、入伍地类别为城市和吸烟为危险因素。多因素分析中有卡介苗接种史和住房类别为楼房为保护因素,肺结核病例接触史、劳动强度重度、吸烟和人际交往密切为危险因素。

Objective To explore the risk factors of pulmonary tuberculosis in servicemen,and to take targeted preventive measures so as to provide the basis for the prevention and control in the future.Methods Literature on the tuberculosis infection in servicemen was retrieved,and the data were collected to establish literature database.Literature available was collected for Meta analysis.Results Univariate analysis showed that odds ratio(OR)and 95%CI were as follows:contact history of tuberculosis 1.498(1.387,1.619),BCG vaccination history 0.736(0.594,0.912),BCG scar 0.608(0.415,0.891),training intensity 1.642(1.310,2.058),type of accommodation 0.752(0.647,0.874),category of enlisted area 1.252(1.139,1.376),body mass index(BMI)0.870(0.818,0.925),and cigarette smoking 1.292(1.174,1.422).According to multivariate analysis,OR and were as follows:training intensity 1.254(1.126,1.397),type of accommodation 0.657(0.524,0.824),contact history of tuberculosis 1.617(1.457,1.795),BCG vaccination history 0.786(0.614,1.008),cigarette smoking 1.331(1.141,1.553),interpersonal relationship 1.427(1.237,1.646).There was statistical significance except the BCG vaccination history in multivariate analysis(P<0.01).Conclusion In univariate analysis,normal BMI buildings as type of accommodation,and presence of BCG vaccination history and BCG scar were protective factors,while high intensity training,contact history of tuberculosis,urban area as enlisted area and cigarette smoking were risk factors.In multivariate analysis,BCG vaccination and buildings as type of accommodation were protective factors,while contact history of tuberculosis,high intensity training,cigarette smoking and close interpersonal relationship were risk factors.