摘要
目的颅内动脉瘤严重威胁着人类的健康,但具体发病机制尚未明确。环状RNA是目前非编码RNA中的研究热点,它具有多种生物学功能并广泛参与了多种疾病的基因表达调控。文章聚焦于颅内动脉瘤与环状RNA的关系,探讨环状RNA对颅内动脉瘤发病机制的潜在作用。
Intracranial aneurysm is a serious threat to human health,but the specific pathogenesis has not yet been identified.Circular RNA is a current research hotspot in non-coding RNA.It has a variety of biological functions and is widely involved in the regulation of gene expression in various diseases.This article focuses on the relationship between intracranial aneurysms and circular RNA,and investigates the potential effect of circular RNA on the pathogenesis of intracranial aneurysms.
作者
路智文
黄清海
Lu Zhiwen;Huang Qinghai(Department of Neurosurgery,Changhai Hospital Affiliated to Naval Medical University,Shanghai,China)
出处
《国际脑血管病杂志》
2020年第2期150-156,共7页
International Journal of Cerebrovascular Diseases
基金
国家重点研发项目(2016YFC1300700)
国家自然科学基金(81771264,81971089)。
关键词
RNA
环状
颅内动脉瘤
微RNAS
信号转导
炎症
RNA
circular
Intracranial aneurysm
MicroRNAs
Signal transduction
Inflammation
