双膦酸盐在正畸治疗中的新进展与展望

New progress and prospect of bisphosphonate in orthodontic treatment

双膦酸盐(Bisphosphonates,BPs)可高效抑制骨吸收,不仅影响骨骼新陈代谢,而且对正畸治疗中的牙齿移动具有一定作用。最新研究表明,BPs可通过不同机制干扰破骨细胞的骨吸收,具有限制支抗牙齿的移动,减少牙根吸收,保持腭部快速扩弓疗效,加速颅面部牵张成骨的骨重建过程,并防止骨钉感染与松动等诸多作用。本文就BPs作用机制、应用新进展和展望做归纳总结。

Bisphosphonates(BPs)can effectively inhibit bone resorption,which not only affects bone metabolism,but also has a certain effect on tooth movement in orthodontic treatment.Recent new studies have shown that BPs interfere with bone resorption of osteoclasts through different mechanisms,restrict the movement of anchorage teeth,reduce root resorption,and maintain the effect of rapid palatal expansion.Therefore,BPs can accelerate the process of bone reconstruction in craniofacial stretching,and prevent the infection induced by bone nail and the tooth loosening.This article summarizes new progress and prospect of BPs regarding to the mechanism and the assessment of benefits and risks for better and rational use in orthodontic treatment.