新型冠状病毒肺炎治疗中人免疫球蛋白的合理使用与药学监护

Rational Use and Pharmaceutical Care of Human Immunoglobulin in the Treatment of Coronavirus Disease 2019

目的探讨人免疫球蛋白在新型冠状病毒肺炎治疗中的合理使用与药学监护要点。方法查阅文献,整理静脉用人免疫球蛋白的作用机制、适应证、感染性疾病应用概况、剂量、药代动力学特点,以及对实验室指标的影响和不良反应等特点,提出合理用药建议。结果与结论人免疫球蛋白在新型冠状病毒肺炎的治疗中缺乏直接使用证据,不建议常规应用。免疫缺陷或疾病进展迅速的患者可考虑使用,但应把握剂量,注意输注速率。使用过程中应动态监测患者血浆球蛋白水平,加强药学监护。

Objective To investigate the rational use and pharmaceutical care of human immunoglobulin in the treatment of coronavirus disease 2019(COVID-19).Methods The mechanism,indications,general application in infectious diseases,dosage,pharmacokinetic characteristics,effects on laboratory examination indexes and adverse reactions of intravenous human immunoglobulin were summarized by reviewing the literature,and the drug recommendations were put forward.Results and Conclusion There was no direct evidence for the use of human immunoglobulin in the treatment of the COVID-19,so it is not recommended to use it routinely.Patients with immunodeficiency or rapid disease progression may be considered for use.However,the dosage and infusion speed should be controlled.The globulin levels in plasma should be dynamically monitored during the use and pharmaceutical care should be strengthened.