丁苯酞联合多巴丝肼治疗老年帕金森病临床评价

Butylphthalide Combined with Basilazide in the Treatment of Senile Parkinson’s Disease

目的探讨丁苯酞联合多巴丝肼治疗老年帕金森病的临床疗效及对患者认知功能和CT血管造影(CTA)结果的影响。方法选取保定市第二中心医院2017年1月至2019年1月收治的老年帕金森病患者92例,按奇偶法分为观察组和对照组,各46例。两组患者均予多巴丝肼片口服,观察组患者加服丁苯酞软胶囊,均治疗12周。结果观察组总有效率为89.13%,明显高于对照组的71.74%(P<0.05);观察组患者的简易智力状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)评分均明显高于对照组(P<0.05),钙化斑块数明显多于对照组,钙化斑块厚度均明显小于对照组(P<0.05),β淀粉样蛋白(Aβ1-42)、表皮生长因子(EGF)表达水平均明显高于对照组,同型半胱氨酸(HCY)表达水平明显低于对照组(P<0.05);观察组与对照组不良反应发生率相当(15.22%比8.70%,P>0.05)。结论丁苯酞联合多巴丝肼治疗老年帕金森病,能改善患者的认知功能状态及血清学指标水平,减少其脑部钙化点数量,缩小钙化斑块。

Objective To study the effect of butylphthalide combined with basilazide on cognitive function and CT angiography(CTA)results in elderly Parkinson’s disease.Methods A total of 92 elderly patients with Parkinson’s disease admitted to the hospital from January 2017 to January 2019 were selected and divided into observation group and control group according to parity method,46 cases in each group.The control group was treated with basilazide,while the observation group was added with butyryl benzene.Both groups were treated for 12 consecutive weeks.Results The total effective rate of the observation group was 89.13%,which was significantly higher than 71.74%of the control group(P<0.05).After treatment,the scores of mini-mental state examination(MMSE)and Montreal cognitive assessment(MoCA)in the observation group were significantly higher than those in the control group(P<0.05);the number of calcified plaques in the observation group were obviously less than the control group,while the and size of calcified plaques were significantly less than those in the control group(P<0.05);the levels of beta amyloid protein(Aβ1-42)and epidermal growth factor(EGF)were significantly higher,while the homocysteine(HCY)in the observation group significantly lower than those in the control group(P<0.05).The incidence of adverse reactions in the two groups were similar(15.22%vs.8.70,P>0.05).Conclusion Butylphthalide combined with basilazide in the treatment of senile Parkinson’s disease can improve the cognitive function and the serological indicators of patients,reduce the number and size of calcification points in patients’brain.