鼻息肉动物模型及其研究进展

Progress of the formation of nasal polyps in animal

慢性鼻-鼻窦炎是一种最常见的慢性呼吸道炎性疾病之一,伴有鼻息肉的慢性鼻窦炎病因及发病机制尚不清楚,治疗有一定困难,是目前研究的重点.鼻息肉动物模型的建立和应用是研究人类鼻息肉发病机制及探索新的治疗的重要方法.本文回顾目前提出的鼻息肉动物模型,对其造模方法、评价标准及模型应用做一综述研究.

Chronic rhinosinusitis is one of the most common chronic respiratory inflammatory diseases.The etiology and pathogenesis of chronic rhinosinusitis with nasal polyps are still unclear,causing difficulty to cure the disease.It is the focus of research concerning this disease at the moment.The establishment and application of the animal model of nasal polyps is a significant study method of the pathogenesis of human nasal polyps and the exploration of new treatment.This paper reviews the present animal models of nasal polyps and does a summary study on their modeling methods,evaluation criteria and model application.