MRI测量中国汉族不同性别正常成人枕叶体积

MRI measurement of occipital lobe volume in different genders of healthy Han Chinese adults

目的采用MRI测量不同性别中国汉族正常成人枕叶体积。方法于中国汉族健康成年脑数据库中选取200名志愿者,采集大脑三维磁化预备梯度回波T1WI。手动勾画ROI,测量左、右侧枕叶体积及全脑体积。将测量结果标准化,比较不同性别左、右侧枕叶体积的差异,分析枕叶体积与年龄的关系以及性别、年龄对枕叶体积的影响。结果正常成人枕叶体积(105.37±10.41)cm 3,标准化后为(105.44±9.20)cm 3。标准化前男性与女性大脑枕叶体积[(111.34±9.15)cm 3和(99.38±7.85)cm 3]及标准化后男性与女性枕叶体积[(111.39±7.31)cm 3和(99.48±6.72)cm 3]差异均有统计学意义(t=9.91、12.01,P均<0.05)。标准化前、后男性左、右侧枕叶体积及女性左、右侧枕叶体积差异均无统计学意义(P均>0.05)。标准化前后男性、女性枕叶体积与年龄均无明显相关(标准化前r=-0.01、0.18,P=0.90、0.08,标准化后r=0.05、0.01,P=0.64、0.92)。性别及年龄对枕叶体积的影响无明显交互作用。结论中国健康成年人枕叶体积男性大于女性,双侧枕叶体积基本一致。枕叶体积不易随年龄增长而出现萎缩。

Objective To measure the occipital lobe volume in different genders of healthy Han Chinese adults with MRI.Methods A total of 200 volunteers were selected from the healthy adult brain database of Han nationality in China.Whole-brain images were obtained using 3D magnetization prepared rapid acquisition gradient echo T1W sequence.The volume of left and right occipital lobes and whole brain volume were measured with manually sketching ROIs.Then the measured data were standardized,and the volume of left and right lateral occipital lobe were compared between different genders,the relation of the occipital lobe volume and age was analyzed,and the influence of gender and age to occipital lobe volume was analyzed.Results The occipital lobe volume of normal adult was(105.37±10.41)cm 3,which was(105.44±9.20)cm 3 after standardization.Before standardization,the volume of occipital lobe in male adults([111.34±9.15]cm 3)was statistically different from that in females([99.38±7.85]cm 3),while after standardization,the volume of occipital lobe in male adults([111.39±7.31]cm 3)was also statistically different from that in females([99.48±6.72]cm 3,t=9.91,12.01,both P<0.05).There was no statistical difference of left and right occipital lobe volume between male adults and female adults before and after standardization(all P>0.05).Before and after standardization,no obvious correlation of occipital lobe volume with age in males or in females was observed(r=-0.01,0.18,P=0.90,0.08;r=0.05,0.01,P=0.64,0.92).There was no interaction between genders nor age on occipital lobe volume.Conclusion The occipital lobe volume of healthy male adults is larger than that of females,and the volume of bilateral occipital lobe is basically the same in different genders.The occipital lobe volume is less likely to atrophy with age.