祛腐生肌治疗对短暂高糖暴露者难愈性创面的疗效

目的观察祛腐生肌治疗对妇科术后短暂高糖暴露患者创面愈合的临床疗效.方法将80例妇科术后短暂高糖暴露患者按随机数字法分成两组.患者经伤口清创处理后,常规治疗组隔日使用碘伏和凡士林纱布换药,去腐生肌组隔日经碘伏消毒后使用祛腐生肌药物治疗,两组患者在入院时、治疗5d、10d、15d后计算创面坏死组织炎症积分,测定表皮生长因子(EGF)的表达,测定创面愈合率以评价临床疗效.结果两组患者经过5d治疗,EGF的表达以及创面愈合率均上升,创面坏死组织炎症评分下降,组间与组内比较差异有统计学意义(P<0.05),两组患者治疗措施与时间在创面坏死组织评分、EGF、创面愈合率上存在交互作用(P<0.05).结论祛腐生肌治疗可有效促进妇科术后短暂高糖暴露患者难愈性创面的愈合,具有较好的临床疗效和适用性.

Objective To observe the clinical effect of remove putrefying muscle therapy on wound healing in patients with transient hyperglycemia after gynecological surgery.Methods 80 patients with transient hyperglycemia after gynecological surgery were divided into experimental group(n=40)and observation group(n=40)by random number method.Both groups were treated with debridement.The observation group was treated with iodide and vaseline gauze every other day,and the experimental group was treated with remove putrefying muscle every other day after iodide disinfection.The expression of EGF was measured on 5d,lOd and 15d,and the score of wound necrosis tissue and the wound healing rate were measured to evaluate the clinical efficacy.Results After 5d of treatment,the expression of EGF and wound healing rate of the two groups increased,while the score of wound necrosis tissue decreased.There was a statistical difFerence between the tAvo groups and within the group(P<0.05),and there was an interaction between the treatment measures and time in the EGF,wound necrosis tissue score and wound healing rate of the two groups(P<0.05).Conclusion The remove putrefying muscle therapy can effectively promote the healing of refractory wounds in patients with transient hyperglycemia after gynecological surgery,which has a good clinical effect and applicability.