灵芝孢子粉对中重度慢性阻塞性肺疾病的随访研究

The clinical outcome of Ganoderma lucidum spore powder for moderate or severe chronic obstructive pulmonary disease patients

目的观察灵芝孢子粉对中重度慢性阻塞性肺疾病(COPD)稳定期患者肺功能、6分钟步行距离及T淋巴细胞亚群的影响。方法选取稳定期中重度COPD门诊患者19例,服用灵芝孢子粉6个月后观察患者服药前后肺功能的变化及循环血液中CD4^+、CD8^+T淋巴细胞的比例变化,症状评分(CAT评分)以及对6 MWT的影响。结果服用灵芝孢子粉6个月后,中重度COPD患者的六分钟步行距离延长,平均增加19 m(P<0.01),患者的CAT评分也有改善(P<0.01),患者肺功能与服药前相比有改善趋势,其中FEV 1较服用前平均增加60 mL(P>0.05),FVC平均增加为130 mL(P<0.01),FEV 1/FVC比例降低0.47(P>0.05);外周血CD4^+T淋巴细胞比例增加(P<0.01),CD8^+和CD4^+/CD8^+T淋巴细胞亚群比例未见明显变化(P>0.05)。结论服用灵芝孢子粉6个月后对肺功能无明显作用,但能改善中重度COPD患者的CAT症状评分,可能与升高CD4^+T淋巴细胞比例有关。

Objective To observe the effects of Ganoderma lucidum spore powder on lung function,6-minute walking distance and T lymphocyte subsets in patients with moderate to severe chronic obstructive pulmonary disease(COPD).Methods Nineteen patients with moderate-to-severe COPD outpatients in stable phase were enrolled.After taking Ganoderma lucidum spore powder for 6 months,the changes of lung function and the proportion of CD4^+and CD8^+T lymphocytes in circulating blood,the symptom score(CAT score)and impact on the 6 MWT were observed.Results After taking Ganoderma lucidum spore powder for 6 months,the six-minute walking distance of patients with moderate to severe COPD was prolonged,with an average increase of 19 meters(P<0.01).The patient s CAT score was also improved(P<0.01).There was an improvement trend in increasing average FEV1 by 60 mL(P>0.05),FVC increased to 130 mL(P<0.01)and the FEV1/FVC ratio decreased by 0.47(P>0.05).The proportion of CD4^+T lymphocytes in peripheral blood increased(P<0.01),and the proportion of CD8^+and CD4^+/CD8^+T lymphocyte subsets did not reach the significance(P>0.05).Conclusion After taking Ganoderma lucidum spore powder for 6 months,it has no significant effect on lung function,but it may improve the CAT symptom score of patients with moderate to severe COPD,which may be related to the increase of CD4^+T lymphocyte ratio.