银蒲八正散加减联合头孢克洛治疗女性湿热下注型复发性尿路感染的临床观察

The Clinical Efficacy of Yinpu Bazheng San Combined with Cefaclor Capsule in the Treatment of Recurrent Urinary Tract Infections in Female Patients with Downward Flow of Damp and Heat

目的观察李琦教授运用银蒲八正散加减联合头孢克洛治疗女性湿热下注型复发性尿路感染(recurrent urinary tract infection,RUTI)的临床疗效。方法选择2016年12月-2018年12月云南中医药大学第一附属医院确诊为RUTI的女性患者共80例,随机分为治疗组和对照组各40例,对照组患者根据药敏试验,予敏感抗生素治疗2周至尿常规转阴,再口服头孢克洛胶囊以维持治疗6周。在此基础上,治疗组加用银蒲八正散口服,疗程8周。观察两组患者外周血T淋巴细胞亚群,临床症状缓解时间,临床症状消失时间,中医证候评分及疗效情况。结果治疗1周后和治疗结束时,治疗组中医评分较对照组均明显好转,症状缓解时间和症状消失时间均明显低于对照组,治疗组患者外周血CD4^+、CD8^+、CD4^+/CD8^+改善情况明显优于对照组,差异具有统计学意义(P<0.05)。结论银蒲八正散加减结合抗生素治疗女性湿热下注型复发性尿路感染效果明显,值得临床推广。

Objective To observe the clinical efficacy of Professor Li Qi's Yinpu Bazheng San combined with Cefaclor capsule in the treatment of recurrent urinary tract infections in female patients with downward flow of damp and heat.Methods A total of 80 female patients diagnosed with RUTI in our hospital from December 2016 to February 2018 were randomly divided into treatment group and control group.According to the drug susceptibility test,the sensitive antibiotic was treated for 2 weeks until the urine routinely turned negative,and then the oral Cefaclor capsule was taken to maintain the treatment for 6 weeks in the control group.On this basis,the treatment group was treated with Yinpu Bazheng Powder orally.The treatment continued 8 weeks.The peripheral blood T lymphocyte subsets,clinical symptom relief time,clinical symptom disappearance time,TCM symptom score and efficacy were observed.Results After 1 week of treatment and at the end of treatment,the scores of TCM in the treatment group were significantly improved than those in the control group.The time of symptom relief and the disappearance time of symptoms were significantly lower than those of the control group.The improvement of CD4^+,CD8^+and CD4^+/CD8^+in the peripheral blood of the treatment group was obviously.Compared with the control group,the differences were statistically significant(P<0.05).Conclusion Self-made Yinpu Bazheng San combined with antibiotics were effective in the treatment of recurrent urinary tract infections in female patients with downward flow of damp and heat.It is worthy of clinical promotion.